DIS3L2

Last updated
DIS3L2
Identifiers
Aliases DIS3L2 , FAM6A, PRLMNS, hDIS3 like 3'-5' exoribonuclease 2
External IDs OMIM: 614184 MGI: 2442555 HomoloGene: 62417 GeneCards: DIS3L2
Gene location (Human)
Ideogram human chromosome 2.svg
Chr. Chromosome 2 (human) [1]
Human chromosome 2 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 2q37.1Start231,961,245 bp [1]
End232,344,350 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257281
NM_001257282
NM_152383

NM_001172157
NM_153530

RefSeq (protein)

NP_001244210
NP_001244211
NP_689596

NP_001165628
NP_705758

Location (UCSC) Chr 2: 231.96 – 232.34 Mb Chr 1: 86.7 – 87.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene. [5] The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].

Contents

Clinical significance

Mutations in DIS3L2 cause Perlman syndrome. [6]

Related Research Articles

DIS3 protein-coding gene in the species Homo sapiens

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.

Centrin 3 protein-coding gene in the species Homo sapiens

Centrin-3 is a protein that in humans is encoded by the CETN3 gene. It belongs to the centrin family of proteins.

PWP1 protein-coding gene in the species Homo sapiens

Periodic tryptophan protein 1 homolog is a protein that in humans is encoded by the PWP1 gene.

IWS1 protein-coding gene in the species Homo sapiens

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.

ALG3 protein-coding gene in the species Homo sapiens

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that, in humans, is encoded by the ALG3 gene.

MTO1 protein-coding gene in the species Homo sapiens

Protein MTO1 homolog, mitochondrial is a protein that in humans is encoded by the MTO1 gene.

DBR1 protein-coding gene in the species Homo sapiens

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.

SPC24 protein-coding gene in the species Homo sapiens

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.

DCP1B protein-coding gene in the species Homo sapiens

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.

SSH3 protein-coding gene in the species Homo sapiens

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.

TSEN2 protein-coding gene in the species Homo sapiens

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.

C16orf84 protein-coding gene in the species Homo sapiens

CTU2 is a human gene located on chromosome 16. The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.

PTBP2 protein-coding gene in the species Homo sapiens

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.

DIS3L protein-coding gene in the species Homo sapiens

DIS3-like exonuclease 1 is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.

PRPF40B protein-coding gene in the species Homo sapiens

Pre-mRNA-processing factor 40 homolog B is a protein that in humans that is encoded by the PRPF40B gene.

DDI1 protein-coding gene in the species Homo sapiens

DNA-damage inducible 1 homolog 1 is a protein. In humans it is encoded by the DDI1 gene.

Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae) protein-coding gene in the species Homo sapiens

SLX1 structure-specific endonuclease subunit homolog B is a protein in humans that is encoded by the SLX1B gene.

LIN28B (gene) protein-coding gene in the species Homo sapiens

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene.

RNASEH2C protein-coding gene in the species Homo sapiens

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits, and degrades the RNA of RNA:DNA hybrids.

Poly(a) binding protein interacting protein 2b protein-coding gene in the species Homo sapiens

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144535 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053333 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: DIS3 mitotic control homolog (S. cerevisiae)-like 2" . Retrieved 2013-03-10.
  6. "OMIM Entry - # 267000 - PERLMAN SYNDROME; PRLMNS". www.omim.org. Retrieved 2020-01-25.

Further reading