DNA polymerase kappa

POLK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T94, 2LSI, 2OH2, 2W7O, 2W7P, 3IN5, 3PZP, 4BA9, 4GK5, 4U6P, 4U7C
Identifiers
Aliases	POLK , DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappa
External IDs	OMIM: 605650; MGI: 1349767; HomoloGene: 32140; GeneCards: POLK; OMA:POLK - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q13.3 Start 75,511,756 bp [1] End 75,601,144 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum superficial temporal artery epithelium of colon mucosa of paranasal sinus skin of hip trabecular bone monocyte islet of Langerhans synovial membrane n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity damaged DNA binding DNA-directed DNA polymerase activity DNA binding nucleotidyltransferase activity metal ion binding protein binding Cellular component nucleoplasm nucleus nuclear body site of DNA damage Biological process nucleotide-excision repair, DNA gap filling DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision DNA biosynthetic process nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus cellular response to UV error-prone translesion synthesis error-free translesion synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51426 27015 Ensembl ENSG00000122008 ENSMUSG00000021668 UniProt Q9UBT6 Q9QUG2 RefSeq (mRNA) NM_016218 NM_001345921 NM_001345922 NM_012048 RefSeq (protein) NP_001332850 NP_001332851 NP_057302 NP_057302.1 NP_001334531 NP_001334532 NP_001334533 NP_001334535 NP_036178 Location (UCSC) Chr 5: 75.51 – 75.6 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase kappa is a DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis. ^{[4] [5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000122008 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ". Genes Dev. 14 (13): 1589–94. doi:10.1101/gad.14.13.1589. PMC   316741 . PMID   10887153.
5. Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily". Proc Natl Acad Sci U S A. 96 (21): 11922–7. Bibcode:1999PNAS...9611922G. doi: 10.1073/pnas.96.21.11922 . PMC   18388 . PMID   10518552.
6. "Entrez Gene: POLK Polymerase (DNA directed) kappa".

Further reading

• Bavoux C, Hoffmann JS, Cazaux C (2005). "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa". Biochimie. 87 (7): 637–46. doi:10.1016/j.biochi.2005.02.007. PMID   15989980.
• Ogi T, Kato T, Kato T, Ohmori H (2000). "Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB". Genes Cells. 4 (11): 607–18. doi: 10.1046/j.1365-2443.1999.00289.x . PMID   10620008. S2CID   6554870.
• Johnson RE, Prakash S, Prakash L (2000). "The human DINB1 gene encodes the DNA polymerase Polθ". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3838–43. Bibcode:2000PNAS...97.3838J. doi: 10.1073/pnas.97.8.3838 . PMC   18103 . PMID   10760255.
• Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC (2001). "Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene". J. Biol. Chem. 276 (1): 92–8. doi: 10.1074/jbc.M004413200 . PMID   11024016.
• Haracska L, Unk I, Johnson RE, et al. (2002). "Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA". Mol. Cell. Biol. 22 (3): 784–91. doi:10.1128/MCB.22.3.784-791.2002. PMC   133560 . PMID   11784855.
• Washington MT, Johnson RE, Prakash L, Prakash S (2002). "Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1910–4. Bibcode:2002PNAS...99.1910W. doi: 10.1073/pnas.032594399 . PMC   122293 . PMID   11842189.
• Suzuki N, Ohashi E, Kolbanovskiy A, et al. (2002). "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)". Biochemistry. 41 (19): 6100–6. doi:10.1021/bi020049c. PMID   11994005.
• Fischhaber PL, Gerlach VL, Feaver WJ, et al. (2002). "Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides". J. Biol. Chem. 277 (40): 37604–11. doi: 10.1074/jbc.M206027200 . PMID   12145297.
• Bergoglio V, Bavoux C, Verbiest V, et al. (2003). "Localisation of human DNA polymerase kappa to replication foci". J. Cell Sci. 115 (Pt 23): 4413–8. doi:10.1242/jcs.00162. PMID   12414988. S2CID   84437951.
• Haracska L, Prakash L, Prakash S (2003). "Role of human DNA polymerase κ as an extender in translesion synthesis". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16000–5. doi: 10.1073/pnas.252524999 . PMC   138554 . PMID   12444249.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wolfle WT, Washington MT, Prakash L, Prakash S (2003). "Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions". Genes Dev. 17 (17): 2191–9. doi:10.1101/gad.1108603. PMC   196459 . PMID   12952891.
• Haracska L, Prakash L, Prakash S (2003). "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair". Genes Dev. 17 (22): 2777–85. doi:10.1101/gad.1146103. PMC   280626 . PMID   14630940.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Suzuki N, Itoh S, Poon K, et al. (2004). "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa". Biochemistry. 43 (20): 6304–11. doi:10.1021/bi0360298. PMID   15147214.
• Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells. 9 (6): 523–31. doi:10.1111/j.1356-9597.2004.00747.x. PMID   15189446. S2CID   24470762.
• Washington MT, Minko IG, Johnson RE, et al. (2004). "Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ". Mol. Cell. Biol. 24 (13): 5687–93. doi:10.1128/MCB.24.13.5687-5693.2004. PMC   480884 . PMID   15199127.
• Uljon SN, Johnson RE, Edwards TA, et al. (2005). "Crystal structure of the catalytic core of human DNA polymerase kappa". Structure. 12 (8): 1395–404. doi: 10.1016/j.str.2004.05.011 . PMID   15296733.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9UBT6 (DNA polymerase kappa) at the PDBe-KB .