DOK3

DOK3
Identifiers
Aliases	DOK3 , DOKL, docking protein 3
External IDs	OMIM: 611435; MGI: 1351490; HomoloGene: 8448; GeneCards: DOK3; OMA:DOK3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 177,501,904 bp [1] End 177,511,274 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 B1 Start 55,671,044 bp [2] End 55,677,109 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte spleen right lung lymph node bone marrow upper lobe of left lung trabecular bone appendix Top expressed in granulocyte blood spleen tibiofemoral joint bone marrow lymph node mesenteric lymph nodes fetal liver hematopoietic progenitor cell stroma of bone marrow subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane cytoplasm plasma membrane secretory granule membrane ficolin-1-rich granule membrane Biological process neutrophil degranulation Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79930 27261 Ensembl ENSG00000146094 ENSMUSG00000035711 UniProt Q7L591 Q9QZK7 RefSeq (mRNA) NM_001144875 NM_001144876 NM_001308235 NM_001308236 NM_024872 NM_001375794 NM_001375795 NM_001375796 NM_001375797 NM_001375798 NM_001375799 NM_001384137 NM_001384138 NM_001384139 NM_013739 RefSeq (protein) NP_001138347 NP_001138348 NP_001295164 NP_001295165 NP_079148 NP_001362723 NP_001362724 NP_001362725 NP_001362726 NP_001362727 NP_001362728 NP_001371066 NP_001371067 NP_001371068 NP_038767 Location (UCSC) Chr 5: 177.5 – 177.51 Mb Chr 13: 55.67 – 55.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000146094 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035711 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC   85490 . PMID   10733577.
6. Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID   12595900. S2CID   24417010.
7. "Entrez Gene: DOK3 docking protein 3".

Further reading

• Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. doi:10.1128/MCB.19.12.8314. PMC   84915 . PMID   10567556.
• Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC   2150770 . PMID   11470823.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. doi:10.1128/MCB.24.6.2332-2343.2004. PMC   355862 . PMID   14993273.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura SI, Natsume T, Yamanashi Y (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): 143–51. doi: 10.1111/j.1365-2443.2006.00926.x . PMID   16436051. S2CID   42571721.