DOK5

DOK5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J0W
Identifiers
Aliases	DOK5 , C20orf180, IRS-6, IRS6, docking protein 5
External IDs	OMIM: 608334 MGI: 1924079 HomoloGene: 10195 GeneCards: DOK5
Gene location (Human)
Chr.	Chromosome 20 (human)
End	54,651,169 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	170,879,769 bp
RNA expression pattern
	More reference expression data
Orthologs
	55816
	76829
	ENSG00000101134
	ENSMUSG00000027560
	Q9P104
	Q91ZM9
	NM_001294161 ; NM_018431 ; NM_177959
	NM_001163686 ; NM_029761
	NP_001281090 ; NP_060901 ; NP_808874
	NP_001157158 ; NP_084037
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 27, 2021

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.^[6]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.^[5]^[7]

Related Research Articles

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.

The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK4 and GRK5. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.

Girdin is a protein that in humans is encoded by the CCDC88A gene.

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101134 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027560 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770 . PMID 11470823.
1 2 "Entrez Gene: DOK5 docking protein 5".
↑ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi: 10.1074/jbc.M403726200 . PMID 15286081.

Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi: 10.1038/414865a . PMID 11780052.
Shi N, Zhou W, Tang K, et al. (2003). "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D. 58 (Pt 12): 2170–2. doi:10.1107/S090744490201644X. PMID 12454490.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi: 10.1038/sj.gene.6363891 . PMID 12595900.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi: 10.1074/jbc.M212430200 . PMID 12730241.
Crowder RJ, Enomoto H, Yang M, et al. (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi: 10.1074/jbc.M403726200 . PMID 15286081.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shi L, Yue J, You Y, et al. (2007). "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101134 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027560 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11470823-5] 1 2 Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770 . PMID 11470823.

[entrez-6] 1 2 "Entrez Gene: DOK5 docking protein 5".

[pmid15286081-7] Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi: 10.1074/jbc.M403726200 . PMID 15286081.

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DOK5

Contents

Function

Interactions

Related Research Articles

References

Further reading