DPYSL5

DPYSL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B90, 4B91, 4B92
Identifiers
Aliases	DPYSL5 , CRAM, CRMP-5, CRMP5, Ulip6, dihydropyrimidinase like 5, CV2, RTSC4
External IDs	OMIM: 608383; MGI: 1929772; HomoloGene: 41347; GeneCards: DPYSL5; OMA:DPYSL5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 26,847,747 bp [1] End 26,950,351 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 30,868,908 bp [2] End 30,956,719 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone C1 segment nucleus accumbens putamen substantia nigra caudate nucleus corpus callosum hypothalamus inferior ganglion of vagus nerve Top expressed in tail of embryo ganglionic eminence ventricular zone lumbar spinal ganglion neural layer of retina Rostral migratory stream superior cervical ganglion genital tubercle epiblast seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds dihydropyrimidinase activity Cellular component cytoplasm cytosol soma dendrite Biological process signal transduction nervous system development axon guidance pyrimidine nucleobase catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56896 65254 Ensembl ENSG00000157851 ENSMUSG00000029168 UniProt Q9BPU6 Q9EQF6 RefSeq (mRNA) NM_020134 NM_001253723 NM_001253724 NM_023047 NM_001356948 NM_001356949 RefSeq (protein) NP_001240652 NP_001240653 NP_064519 NP_075534 NP_001343877 NP_001343878 Location (UCSC) Chr 2: 26.85 – 26.95 Mb Chr 5: 30.87 – 30.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene. ^{[5] [6] [7]}

Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000157851 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029168 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi: 10.1074/jbc.M910126199 . PMID   10851247.
6. Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi: 10.1016/S0014-5793(00)01952-9 . PMID   11034345. S2CID   42248702.
7. "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".

Further reading

• Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID   12838519. S2CID   36493404.
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi: 10.1074/jbc.M003277200 . PMID   10956643.
• Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID   11220734. S2CID   3239861.
• Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes". J. Neurosci. 21 (18): 7203–14. doi:10.1523/JNEUROSCI.21-18-07203.2001. PMC   6763003 . PMID   11549731.
• Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC   125392 . PMID   12093729.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9BPU6 (Dihydropyrimidinase-related protein 5) at the PDBe-KB .