DRG1

DRG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EKI
Identifiers
Aliases	DRG1 , NEDD3, developmentally regulated GTP binding protein 1
External IDs	OMIM: 603952; MGI: 1343297; HomoloGene: 3060; GeneCards: DRG1; OMA:DRG1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 31,399,604 bp [1] End 31,530,634 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 3,137,360 bp [2] End 3,216,415 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis male germ cell triceps brachii muscle glutes sperm deltoid muscle tibialis anterior muscle Skeletal muscle tissue of rectus abdominis quadriceps femoris muscle Top expressed in medial ganglionic eminence spermatocyte blastocyst spermatid morula morula embryo epiblast internal carotid artery ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding transcription factor binding protein binding identical protein binding GTPase activity microtubule binding hydrolase activity potassium ion binding metal ion binding Cellular component cytoplasm polysome membrane cytosol nuclear body nucleus Biological process multicellular organism development transcription, DNA-templated cytoplasmic translation positive regulation of microtubule polymerization regulation of mitotic spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4733 13494 Ensembl ENSG00000185721 ENSMUSG00000020457 UniProt Q9Y295 P32233 RefSeq (mRNA) NM_004147 NM_007879 RefSeq (protein) NP_004138 NP_031905 Location (UCSC) Chr 22: 31.4 – 31.53 Mb Chr 11: 3.14 – 3.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000185721 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020457 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi: 10.1016/S0021-9258(18)47271-7 . PMID   7929244.
6. Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID   1449490.
7. "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

Further reading

• Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID   1280421.
• Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID   8649774.
• Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo". Biochim. Biophys. Acta. 1448 (1): 109–14. doi: 10.1016/s0167-4889(98)00129-3 . PMID   9824680.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID   10760581.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID   12702552.
• Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene. 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID   15184886. S2CID   24392094.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi: 10.1158/0008-5472.CAN-06-0943 . PMID   17178897.