DRG2

DRG2
Identifiers
Aliases	DRG2 , developmentally regulated GTP binding protein 2
External IDs	OMIM: 602986; MGI: 1342307; HomoloGene: 1061; GeneCards: DRG2; OMA:DRG2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p11.2 Start 18,087,892 bp [1] End 18,107,970 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B2|11 37.81 cM Start 60,345,417 bp [2] End 60,359,580 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right lobe of liver anterior pituitary apex of heart body of uterus gastrocnemius muscle right ovary right lobe of thyroid gland left ovary canal of the cervix Top expressed in otic vesicle morula neural layer of retina internal carotid artery otic placode external carotid artery saccule tail of embryo epiblast ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding RNA binding GTPase activity hydrolase activity metal ion binding Cellular component membrane mitochondrion intracellular membrane-bounded organelle nucleoplasm cytoplasm cytosol nucleus Biological process signal transduction cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1819 13495 Ensembl ENSG00000108591 ENSMUSG00000020537 UniProt P55039 Q9QXB9 RefSeq (mRNA) NM_001388 NM_001330144 NM_021354 RefSeq (protein) NP_001317073 NP_001379 NP_067329 Location (UCSC) Chr 17: 18.09 – 18.11 Mb Chr 11: 60.35 – 60.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene. ^{[5] [6] [7]}

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000108591 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020537 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 274–5. doi:10.1159/000134741. PMID   9605870.
6. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi: 10.1016/S0021-9258(18)47271-7 . PMID   7929244.
7. "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2".

Further reading

• Sprang SR (1998). "G proteins, effectors and GAPs: structure and mechanism". Curr. Opin. Struct. Biol. 7 (6): 849–56. doi:10.1016/S0959-440X(97)80157-1. PMID   9434906.
• Liang Y, Wang A, Belyantseva IA, et al. (2000). "Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2". Genomics. 61 (3): 243–58. doi:10.1006/geno.1999.5976. PMID   10552926.
• Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID   10760581.
• Vlangos CN, Das P, Patel PI, Elsea SH (2000). "Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval". Cytogenet. Cell Genet. 88 (3–4): 283–5. doi:10.1159/000015539. PMID   10828610. S2CID   32462696.
• Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC   186594 . PMID   11997338.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Song H, Kim SI, Ko MS, et al. (2005). "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis". J. Biochem. 135 (3): 331–5. doi: 10.1093/jb/mvh040 . PMID   15113831.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.