Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. [5] [6]
Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. [5] [6]
Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [6]
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.
Hairless, also known as H, is a well-characterized Drosophila gene. Since Hairless is a dominant loss of function mutation, many mutations to Hairless are embryonic lethal, but there are several viable hairless mutants. This specific Drosophila gene is involved in the Notch signaling pathway (NSP) by acting as a suppressor of the organism's Notch signaling. This interaction of the NSP can be seen in Figure 1.
Neurogenic locus notch homolog protein 3(Notch 3) is a protein that in humans is encoded by the NOTCH3 gene.
Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway. The Notch Signaling Pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339.
Neurogenic locus notch homolog protein 1(Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single-pass transmembrane receptor.
Neurogenic locus notch homolog 4(Notch 4) is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.
Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.
Neurogenic locus notch homolog protein 2 is a protein that in humans is encoded by the NOTCH2 gene.
Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.
Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.
Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.
Jagged-2 is a protein that in humans is encoded by the JAG2 gene.
Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.
Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.
RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.
Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.
Deltex E3 ubiquitin ligase 3 is a protein that in humans is encoded by the DTX3 gene.
Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene.
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