DTX1

DTX1
Identifiers
Aliases	DTX1 , hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
External IDs	OMIM: 602582; MGI: 1352744; HomoloGene: 74522; GeneCards: DTX1; OMA:DTX1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	113,098,028 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,849,992 bp
RNA expression pattern
	Top expressed in
	spleen; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; nucleus accumbens; ; Brodmann area 9; ; amygdala; ; ganglionic eminence; ; prefrontal cortex;
	Top expressed in
	entorhinal cortex; ; mesenteric lymph nodes; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; motor neuron; ; superior colliculus; ; cerebellar cortex; ; lumbar subsegment of spinal cord; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; transcription coactivator activity ; zinc ion binding ; protein binding ; ubiquitin protein ligase binding ; metal ion binding ; Notch binding ; transferase activity ;
Cellular component	cytoplasm ; nucleus ; nucleoplasm ; cytosol ; nuclear body ;
Biological process	Notch signaling pathway ; cell surface receptor signaling pathway ; glial cell differentiation ; transcription by RNA polymerase II ; regulation of Notch signaling pathway ; negative regulation of T cell differentiation ; negative regulation of neuron differentiation ; protein ubiquitination ; transcription, DNA-templated ; cellular response to leukemia inhibitory factor ; positive regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	1840
	14357
	ENSG00000135144
	ENSMUSG00000029603
	Q86Y01
	Q61010
	NM_004416
	NM_008052
	NP_004407
	NP_032078
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 24, 2024

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.^[5]^[6]

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.^[6]

Interactions

DTX1 has been shown to interact with EP300.^[7]

Related Research Articles

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.

Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway. The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339.

Neurogenic locus notch homolog protein 1(Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single-pass transmembrane receptor.

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

Neurogenic locus notch homolog protein 2 is a protein that in humans is encoded by the NOTCH2 gene.

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.

S-arrestin is a protein that in humans is encoded by the SAG gene.

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.

RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene. This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-κB proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

Neurochondrin is a protein that in humans is encoded by the NCDN gene.

Notch proteins are a family of type 1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in animals. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. Much of what is known about Notch function comes from studies done in Caenorhabditis elegans (C.elegans) and Drosophila melanogaster. Human homologs have also been identified, but details of Notch function and interactions with its ligands are not well known in this context.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135144 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029603 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. S2CID 6812613.
1 2 "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
↑ Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi: 10.1074/jbc.M105245200 . PMID 11564735.

Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H (May 2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 (5): 675–85. doi: 10.1016/S1074-7613(03)00111-0 . PMID 12753744.
Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7. doi: 10.1074/jbc.M301157200 . PMID 12670957.
Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A (Mar 2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994.
Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (Feb 2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231–43. doi: 10.1016/S1074-7613(02)00271-6 . PMID 11869684.
Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi: 10.1074/jbc.M105245200 . PMID 11564735.
Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (Feb 2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". International Journal of Developmental Neuroscience. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. S2CID 21859491.
Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID (Dec 2000). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Human Genetics. 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911. S2CID 38695463.
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (Jul 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi: 10.1016/S0092-8674(00)80336-0 . PMID 9244302. S2CID 16544864.
Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (Aug 1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. doi:10.1242/dev.121.8.2633. PMID 7671825.
Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi: 10.3390/cells12131680 . ISSN 2073-4409. PMC 10340142 . PMID 37443713.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135144 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029603 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9590294-5] Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. S2CID 6812613.

[entrez-6] 1 2 "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".

[pmid11564735-7] Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi: 10.1074/jbc.M105245200 . PMID 11564735.

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DTX1

Contents

Function

Interactions

Related Research Articles

References

Further reading