DTX1

Last updated
DTX1
Identifiers
Aliases DTX1 , hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
External IDs OMIM: 602582; MGI: 1352744; HomoloGene: 74522; GeneCards: DTX1; OMA:DTX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004416

NM_008052

RefSeq (protein)

NP_004407

NP_032078

Location (UCSC) Chr 12: 113.06 – 113.1 Mb Chr 5: 120.82 – 120.85 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. [5] [6]

Contents

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [6]

Interactions

DTX1 has been shown to interact with EP300. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135144 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029603 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID   9590294. S2CID   6812613.
  6. 1 2 "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
  7. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi: 10.1074/jbc.M105245200 . PMID   11564735.

Further reading