DTYMK

DTYMK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E9F, 1E9E, 1NMY, 1E2G, 1E9D, 1E98, 1E2E, 1NN0, 1E2Q, 1E9C, 1E2F, 1NN5, 1E99, 2XX3, 1NMZ, 1E9A, 1E2D, 1E9B, 1NMX, 1NN1, 1NN3
Identifiers
Aliases	DTYMK , CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase
External IDs	OMIM: 188345 MGI: 108396 HomoloGene: 6285 GeneCards: DTYMK
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,675,747 bp [1] End 241,686,944 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 D|1 47.34 cM Start 93,792,576 bp [2] End 93,801,934 bp [2]
Gene ontology Molecular function • transferase activity • nucleotide binding • uridylate kinase activity • kinase activity • thymidylate kinase activity • nucleoside monophosphate kinase activity • ATP binding • nucleoside diphosphate kinase activity Cellular component • mitochondrial intermembrane space • mitochondrial matrix • cytoplasm • mitochondrion • cytosol • nucleus Biological process • nucleobase-containing small molecule interconversion • nucleotide biosynthetic process • response to cadmium ion • phosphorylation • cellular response to growth factor stimulus • dTTP biosynthetic process • response to estrogen • dTDP biosynthetic process • dUDP biosynthetic process • myoblast differentiation • cell population proliferation • nucleoside monophosphate phosphorylation • nucleotide phosphorylation • nucleoside diphosphate phosphorylation • thymidine biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1841	21915
Ensembl	ENSG00000168393	ENSMUSG00000026281
UniProt	P23919	P97930
RefSeq (mRNA)	NM_001165031 NM_012145 NM_001320902 NM_001320903 NM_001320904 NM_001320905	NM_001105667 NM_023136
RefSeq (protein)	NP_001158503 NP_001307831 NP_001307832 NP_001307833 NP_001307834 NP_036277	NP_001099137 NP_075625
Location (UCSC)	Chr 2: 241.68 – 241.69 Mb	Chr 1: 93.79 – 93.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene. ^{[5] [6] [7]} and belongs to thymidylate kinase family of proteins.

References

1. GRCh38: Ensembl release 89: ENSG00000168393 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026281 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC   333717 . PMID   2017365.
6. Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID   8024690.
7. "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

Further reading

• Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2–3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID   11008000.
• Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID   2538159.
• Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver". Cancer Res. 40 (4): 1235–9. PMID   6244089.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID   12614151.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.