DVL3

Last updated
DVL3
Protein DVL3 PDB 1l6o.png
Identifiers
Aliases DVL3 , DRS3, dishevelled segment polarity protein 3
External IDs OMIM: 601368; MGI: 108100; HomoloGene: 20928; GeneCards: DVL3; OMA:DVL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004423

NM_007889
NM_001347176

RefSeq (protein)

NP_004414

NP_001334105
NP_031915

Location (UCSC) Chr 3: 184.16 – 184.17 Mb Chr 16: 20.34 – 20.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene. [5] [6]

Contents

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [6]

Interactions

DVL3 has been shown to interact with DAB2, [7] DVL1 [8] and PRPF3. [9]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000161202 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003233 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–958. doi: 10.1093/hmg/5.7.953 . PMID   8817329.
  6. 1 2 "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
  7. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12). England: 3084–3094. doi:10.1093/emboj/cdg286. ISSN   0261-4189. PMC   162138 . PMID   12805222.
  8. Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6). UNITED STATES: 4414–4422. doi:10.1128/mcb.19.6.4414. ISSN   0270-7306. PMC   104400 . PMID   10330181.
  9. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062). England: 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading