Daniela Wilson

Last updated
Daniela Wilson
Born
Daniela Apreutesei

Comănești, Romania
NationalityRomanian
Alma mater Gheorghe Asachi Technical University of Iași
Known for Systems Chemistry, Polymersomes, Artificial cells and organelles, Nanomedicine, Self-assembly
Awards2016 NWO Aspasia, 2015 NWO Athena Award
Scientific career
Fields Organic Chemistry
Polymer Chemistry
Materials Science
Nanotechnology
Institutions Radboud University Nijmegen, 2010–present
University of Pennsylvania, 2007-2010
Gheorghe Asachi Technical University of Iași, 2003-2007
Thesis Research into the relationship between structure and properties in mesogenic systems  (2007)
Website https://www.ru.nl/systemschemistry/people/content/prof-dr-daniela-wilson/

Daniela A. Wilson is a Romanian scientist of organic chemistry known for her research regarding self-assembly, polymer chemistry and nanomotors. She currently holds the position of professor of systems chemistry at Radboud University Nijmegen and holds a chair at the Institute for Molecules and Materials.

Contents

Education

Daniela Wilson received her higher education in Iași, completing her BSc degree in Chemistry and Physics with distinction at the Gheorghe Asachi Technical University in 2001 and an MSc in Environmental Chemistry with distinction at Alexandru Ioan Cuza University in 2003. She subsequently obtained her PhD in macro-molecular chemistry from Gheorghe Asachi in 2007 under the supervision of Dan Scutaru. Her doctoral thesis on “research into the relationship between structure and properties in mesogenic systems” was awarded summa cum laude. [1]

Career

Wilson moved to the United States in 2007 as a research fellow at University of Pennsylvania where she joined the group of Professor Virgil Percec. In 2010 Wilson moved to the Netherlands where she initially worked with Jan van Hest and Roeland Nolte. In 2012 Wilson was made assistant professor in Bio-organic chemistry and tenured in 2016. After a brief period as associate professor she became acting head of Bio-organic chemistry in 2016 and was appointed as full professor to set up a group in systems chemistry at Radboud University Nijmegen in 2017. [1]

Research

Her early career focused on studying the effects of shape on the self-assembly of liquid crystalline materials, [2] and methodology in organic synthesis utilising nickel mediated cross-coupling reactions. [3] Wilson's research into the development of self-assembled nanomotors involves the design of tiny motors that can move autonomously in specific environments, [4] [5] and on developing nanocarriers that respond to various stimuli such as pH, temperature, or light. [6] A 2017 article in the Irish Times talked about how these nano-devises could be used to deliver drugs in the human body. [7]

Selected publications

Awards and honors

Wilson received the 2015 NWO Science Athena award for outstanding female researchers. [8] In 2016 she received the NML Researcher Award from Nano-Micro Letters . [9]

Related Research Articles

The Suzuki reaction or Suzuki coupling is an organic reaction that uses a palladium complex catalyst to cross-couple a boronic acid to an organohalide. It was first published in 1979 by Akira Suzuki, and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their contribution to the discovery and development of noble metal catalysis in organic synthesis. This reaction is sometimes telescoped with the related Miyaura borylation; the combination is the Suzuki–Miyaura reaction. It is widely used to synthesize polyolefins, styrenes, and substituted biphenyls.

<span class="mw-page-title-main">Nanomotor</span> Molecular device capable of converting energy into movement

A nanomotor is a molecular or nanoscale device capable of converting energy into movement. It can typically generate forces on the order of piconewtons.

The Hiyama coupling is a palladium-catalyzed cross-coupling reaction of organosilanes with organic halides used in organic chemistry to form carbon–carbon bonds. This reaction was discovered in 1988 by Tamejiro Hiyama and Yasuo Hatanaka as a method to form carbon-carbon bonds synthetically with chemo- and regioselectivity. The Hiyama coupling has been applied to the synthesis of various natural products.

The Ullmann reaction or Ullmann coupling, named after Fritz Ullmann, couples two aryl or alkyl groups with the help of copper. The reaction was first reported by Ullmann and his student Bielecki in 1901. It has been later shown that palladium and nickel can also be effectively used.

The Negishi coupling is a widely employed transition metal catalyzed cross-coupling reaction. The reaction couples organic halides or triflates with organozinc compounds, forming carbon-carbon bonds (C-C) in the process. A palladium (0) species is generally utilized as the catalyst, though nickel is sometimes used. A variety of nickel catalysts in either Ni0 or NiII oxidation state can be employed in Negishi cross couplings such as Ni(PPh3)4, Ni(acac)2, Ni(COD)2 etc.

<span class="mw-page-title-main">Richard F. Heck</span> American chemist (1931–2015)

Richard Frederick Heck was an American chemist noted for the discovery and development of the Heck reaction, which uses palladium to catalyze organic chemical reactions that couple aryl halides with alkenes. The analgesic naproxen is an example of a compound that is prepared industrially using the Heck reaction.

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<span class="mw-page-title-main">Catellani reaction</span> Chemical reaction

The Catellani reaction was discovered by Marta Catellani and co-workers in 1997. The reaction uses aryl iodides to perform bi- or tri-functionalization, including C-H functionalization of the unsubstituted ortho position(s), followed a terminating cross-coupling reaction at the ipso position. This cross-coupling cascade reaction depends on the ortho-directing transient mediator, norbornene.

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Virgil Percec is a Romanian-American chemist and P. Roy Vagelos Chair and Professor of Chemistry at the University of Pennsylvania. Expert in organic, macromolecular and supramolecular chemistry including self-assembly, biological membrane mimics, complex chiral systems, and catalysis. Pioneered the fields of liquid crystals with complex architecture, supramolecular dendrimers, Janus dendrimers and glycodendrimers, organic Frank-Kasper phases and quasicrystals, supramolecular polymers, helical chirality, Ni-catalyzed cross-coupling and multiple living and self-interrupted polymerizations. Most of these concepts were inspired by Nature and biological principles.

Shuttle catalysis is used to describe catalytic reactions where a chemical entity of a donor molecule is transferred to an acceptor molecule. In these reactions, while the number of chemical bonds of each reactant changes, the types and total number of chemical bonds remain constant over the course of the reaction. In contrast to many organic reactions which exothermicity practically renders them irreversible, reactions operated under shuttle catalysis are often reversible. However, the position of the equilibrium can be driven to the product side through Le Chatelier’s principle. The driving forces for this equilibrium shift are typically the formation of a gas/precipitation, the use of high ground-state energy reactants or the formation of stabilized products or the excess equivalents of a reactant.

References

  1. 1 2 "Professor Daniela Wilson – Wilson Group @Radboud University". wilson-group.science. Retrieved 2024-10-02.
  2. Percec, Virgil; Imam, Mohammad R.; Peterca, Mihai; Wilson, Daniela A.; Heiney, Paul A. (2009-01-28). "Self-Assembly of Dendritic Crowns into Chiral Supramolecular Spheres". Journal of the American Chemical Society. 131 (3): 1294–1304. doi:10.1021/ja8087778. ISSN   0002-7863.
  3. Rosen, Brad M.; Quasdorf, Kyle W.; Wilson, Daniella A.; Zhang, Na; Resmerita, Ana-Maria; Garg, Neil K.; Percec, Virgil (2011-03-09). "Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds". Chemical Reviews. 111 (3): 1346–1416. doi:10.1021/cr100259t. ISSN   0009-2665. PMC   3055945 . PMID   21133429.
  4. Peng, Fei; Tu, Yingfeng; van Hest, Jan C. M.; Wilson, Daniela A. (2015-09-28). "Self-Guided Supramolecular Cargo-Loaded Nanomotors with Chemotactic Behavior towards Cells". Angewandte Chemie International Edition. 54 (40): 11662–11665. doi:10.1002/anie.201504186. ISSN   1433-7851. PMC   4600232 . PMID   26277327.
  5. Howse, Jonathan (2012). "Autonomous propulsion". Nature Chemistry. 4 (4): 247–248. doi:10.1038/nchem.1318. ISSN   1755-4330. PMID   22437704.
  6. Peng, Fei; Tu, Yingfeng; Wilson, Daniela A. (2017). "Micro/nanomotors towards in vivo application: cell, tissue and biofluid". Chemical Society Reviews. 46 (17): 5289–5310. doi:10.1039/C6CS00885B. hdl: 2066/177161 . ISSN   0306-0012.
  7. Holden, John (2 Feb 2017). "Nanorockets could change the way drugs are delivered: Dutch chemists have demonstrated the remote- controlled movement of nanorockets inside the human body". Irish Times; Dublin. p. 8 via Proquest.
  8. "NWO Science Athena Award".
  9. "NML Researcher Award 2016 for dr. Daniela Wilson (Radboud University) – FMS Research Center". 2016-12-15. Retrieved 2024-10-02.