Daniela Wilson | |
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Born | Daniela Apreutesei Comănești, Romania |
Nationality | Romanian |
Alma mater | Gheorghe Asachi Technical University of Iași |
Known for | Systems Chemistry, Polymersomes, Artificial cells and organelles, Nanomedicine, Self-assembly |
Awards | 2016 NWO Aspasia, 2015 NWO Athena Award |
Scientific career | |
Fields | Organic Chemistry Polymer Chemistry Materials Science Nanotechnology |
Institutions | Radboud University Nijmegen, 2010–present University of Pennsylvania, 2007-2010 Gheorghe Asachi Technical University of Iași, 2003-2007 |
Thesis | Research into the relationship between structure and properties in mesogenic systems (2007) |
Website | https://www.ru.nl/systemschemistry/people/content/prof-dr-daniela-wilson/ |
Daniela A. Wilson is a Romanian scientist of organic chemistry known for her research regarding self-assembly, polymer chemistry and nanomotors. She currently holds the position of professor of systems chemistry at Radboud University Nijmegen and holds a chair at the Institute for Molecules and Materials.
Daniela Wilson received her higher education in Iași, completing her BSc degree in Chemistry and Physics with distinction at the Gheorghe Asachi Technical University in 2001 and an MSc in Environmental Chemistry with distinction at Alexandru Ioan Cuza University in 2003. She subsequently obtained her PhD in macro-molecular chemistry from Gheorghe Asachi in 2007 under the supervision of Dan Scutaru. Her doctoral thesis on “research into the relationship between structure and properties in mesogenic systems” was awarded summa cum laude. [1]
Wilson moved to the United States in 2007 as a research fellow at University of Pennsylvania where she joined the group of Professor Virgil Percec. In 2010 Wilson moved to the Netherlands where she initially worked with Jan van Hest and Roeland Nolte. In 2012 Wilson was made assistant professor in Bio-organic chemistry and tenured in 2016. After a brief period as associate professor she became acting head of Bio-organic chemistry in 2016 and was appointed as full professor to set up a group in systems chemistry at Radboud University Nijmegen in 2017. [1]
Her early career focused on studying the effects of shape on the self-assembly of liquid crystalline materials, [2] and methodology in organic synthesis utilising nickel mediated cross-coupling reactions. [3] Wilson's research into the development of self-assembled nanomotors involves the design of tiny motors that can move autonomously in specific environments, [4] [5] and on developing nanocarriers that respond to various stimuli such as pH, temperature, or light. [6] A 2017 article in the Irish Times talked about how these nano-devises could be used to deliver drugs in the human body. [7]
Wilson received the 2015 NWO Science Athena award for outstanding female researchers. [8] In 2016 she received the NML Researcher Award from Nano-Micro Letters . [9]
The Suzuki reaction or Suzuki coupling is an organic reaction that uses a palladium complex catalyst to cross-couple a boronic acid to an organohalide. It was first published in 1979 by Akira Suzuki, and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their contribution to the discovery and development of noble metal catalysis in organic synthesis. This reaction is sometimes telescoped with the related Miyaura borylation; the combination is the Suzuki–Miyaura reaction. It is widely used to synthesize polyolefins, styrenes, and substituted biphenyls.
A nanomotor is a molecular or nanoscale device capable of converting energy into movement. It can typically generate forces on the order of piconewtons.
The Hiyama coupling is a palladium-catalyzed cross-coupling reaction of organosilanes with organic halides used in organic chemistry to form carbon–carbon bonds. This reaction was discovered in 1988 by Tamejiro Hiyama and Yasuo Hatanaka as a method to form carbon-carbon bonds synthetically with chemo- and regioselectivity. The Hiyama coupling has been applied to the synthesis of various natural products.
The Ullmann reaction or Ullmann coupling, named after Fritz Ullmann, couples two aryl or alkyl groups with the help of copper. The reaction was first reported by Ullmann and his student Bielecki in 1901. It has been later shown that palladium and nickel can also be effectively used.
The Negishi coupling is a widely employed transition metal catalyzed cross-coupling reaction. The reaction couples organic halides or triflates with organozinc compounds, forming carbon-carbon bonds (C-C) in the process. A palladium (0) species is generally utilized as the catalyst, though nickel is sometimes used. A variety of nickel catalysts in either Ni0 or NiII oxidation state can be employed in Negishi cross couplings such as Ni(PPh3)4, Ni(acac)2, Ni(COD)2 etc.
Richard Frederick Heck was an American chemist noted for the discovery and development of the Heck reaction, which uses palladium to catalyze organic chemical reactions that couple aryl halides with alkenes. The analgesic naproxen is an example of a compound that is prepared industrially using the Heck reaction.
Bruce H. Lipshutz is an American chemist. He is a professor at the University of California, Santa Barbara.
In organic chemistry, a cross-coupling reaction is a reaction where two different fragments are joined. Cross-couplings are a subset of the more general coupling reactions. Often cross-coupling reactions require metal catalysts. One important reaction type is this:
Jay Kazuo Kochi was an American physical organometallic chemist who held lectureship at Harvard University, and faculty positions at Case Institute of Technology, 1962-1969,, Indiana University, 1969 to 1984, and the University of Houston, 1984 to 2008.
The Catellani reaction was discovered by Marta Catellani and co-workers in 1997. The reaction uses aryl iodides to perform bi- or tri-functionalization, including C-H functionalization of the unsubstituted ortho position(s), followed a terminating cross-coupling reaction at the ipso position. This cross-coupling cascade reaction depends on the ortho-directing transient mediator, norbornene.
Abigail Gutmann Doyle is a professor of chemistry at the University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry. Her research focuses on the development of new chemical transformations in organic chemistry.
Vy Maria Dong is a Vietnamese-American Chancellor's Professor of Chemistry at the University of California, Irvine (UCI). Dong works on enantioselective catalysis and natural product synthesis. She received the Royal Society of Chemistry's Merck, Sharp & Dohme Award in 2020, the American Chemical Society's Elias James Corey Award in 2019, and the UCI's Distinguished Alumni Award in 2018.
Cross electrophile coupling is a type of cross-coupling reaction that occurs between two electrophiles. It is often catalyzed by transition metal catalyst(s). Unlike conventional cross-coupling reactions of an electrophile with an organometallic reagent, the coupling partners in cross electrophile coupling reactions are both electrophiles. Generally, additional reductant to regenerate active catalyst is needed in this reaction.
Sukbok Chang is a South Korean organic chemist. He is a distinguished professor in the Department of Chemistry at Korea Advanced Institute of Science and Technology (KAIST). He is also the director of the Institute for Basic Science (IBS) Center for Catalytic Hydrocarbon Functionalizations (CCHF). He was an associate editor on ACS Catalysis and has served on the editorial advisory boards of The Journal of Organic Chemistry, Journal of the American Chemical Society, and Accounts of Chemical Research. His major research interest is transition metal catalyzed C-H bond functionalization for the carbon-carbon bond and carbon-heteroatom bond formation.
Helma B. Wennemers is a German organic chemist. She is a professor of organic chemistry at the Swiss Federal Institute of Technology in Zurich.
F. Dean Toste is the Gerald E. K. Branch Distinguished Professor of Chemistry at the University of California, Berkeley and faculty scientist at the chemical sciences division of Lawrence Berkeley National Lab. He is a prominent figure in the field of organic chemistry and is best known for his contributions to gold chemistry and asymmetric ion-pairing catalysis. Toste was elected a member of the National Academy of Sciences in 2020, and a member of the American Academy of Arts and Sciences in 2018.
Xile Hu is a Swiss chemist specialized in catalysis. He is a professor in chemistry at EPFL and leads the Laboratory of Inorganic Synthesis and Catalysis at the School of Basic Sciences.
Marisa C. Kozlowski is an American chemist who is Professor of Organic and Catalysis Chemistry at the University of Pennsylvania. Her research considers asymmetric synthesis and the development of cost effective catalysts. She was elected Fellow of the American Association for the Advancement of Science in 2012 and American Chemical Society in 2013.
Virgil Percec is a Romanian-American chemist and P. Roy Vagelos Chair and Professor of Chemistry at the University of Pennsylvania. Expert in organic, macromolecular and supramolecular chemistry including self-assembly, biological membrane mimics, complex chiral systems, and catalysis. Pioneered the fields of liquid crystals with complex architecture, supramolecular dendrimers, Janus dendrimers and glycodendrimers, organic Frank-Kasper phases and quasicrystals, supramolecular polymers, helical chirality, Ni-catalyzed cross-coupling and multiple living and self-interrupted polymerizations. Most of these concepts were inspired by Nature and biological principles.
Shuttle catalysis is used to describe catalytic reactions where a chemical entity of a donor molecule is transferred to an acceptor molecule. In these reactions, while the number of chemical bonds of each reactant changes, the types and total number of chemical bonds remain constant over the course of the reaction. In contrast to many organic reactions which exothermicity practically renders them irreversible, reactions operated under shuttle catalysis are often reversible. However, the position of the equilibrium can be driven to the product side through Le Chatelier’s principle. The driving forces for this equilibrium shift are typically the formation of a gas/precipitation, the use of high ground-state energy reactants or the formation of stabilized products or the excess equivalents of a reactant.