Virgil Percec

Last updated
Virgil Percec
Percecccc.png
Born (1946-12-08) December 8, 1946 (age 77)
Siret, Romania
Academic background
Education Polytechnic University in Iași
(BA, 1969; PhD, 1976)
Website Professor Virgil Percec

Virgil Percec (born December 8, 1946) [1] is a Romanian-American chemist and P. Roy Vagelos Chair and Professor of Chemistry at the University of Pennsylvania. Expert in organic, macromolecular and supramolecular chemistry including self-assembly, biological membrane mimics, complex chiral systems, and catalysis. Pioneered the fields of liquid crystals with complex architecture, [2] supramolecular dendrimers, Janus dendrimers and glycodendrimers, organic Frank-Kasper phases and quasicrystals, supramolecular polymers, helical chirality, Ni-catalyzed cross-coupling and multiple living and self-interrupted polymerizations. Most of these concepts were inspired by Nature and biological principles.

Contents

Life

Early life

Percec was born in December 1946 in Siret, Romania. His father, Traian was a schoolteacher and painter; his mother was named Virginia. Virgil attended Eudoxiu Hurmuzachi High School in Rădăuți.[ citation needed ]

Education

Percec received his BS in Organic and Macromolecular Chemistry at the Polytechnic University in Iași in 1969 and his PhD in 1976 at the Institute of Macromolecular Chemistry in Iași [3] where he had Cristofor Simionescu as a mentor. In 1981 he defected from his native country and after short postdoctoral stays at the University of Freiburg in Germany (July 1981 with H. -J. Cantow) and University of Akron, US (August 1981 to March 1982 with J. P. Kennedy) he joined the Department of Macromolecular Science of Case Western Reserve University (CWRU) in Cleveland, US in March 1982 as an Assistant Professor. He was promoted to Associate Professor in 1984 and to Professor in 1986. In 1991 he became director of Materials Research Science and Engineering Centers (MRSEC) and in 1993, he was awarded the Leonard Case Jr. Chair at CWRU. In 1999 he moved to the University of Pennsylvania in Philadelphia as P. Roy Vagelos Chair and Professor of Chemistry. He has been repeatedly a Visiting Professor at the Universities of Freiburg, Ulm and at the Max Planck Institute for Polymer Research in Mainz (all in Germany) and at the Royal Institute of Technology in Stockholm, Sweden.

Personal life

Percec and his wife, Simona have a daughter Ivona Percec. [4] She earned a double major in Molecular Biology and Medieval History from Princeton University and received an MD and PhD in Genetics from University of Pennsylvania where she joined the faculty and surgery department. [5]

Research

Percec has made scientific contributions in diverse areas, including the discovery of all helical stereoisomers of polyphenylacetylene, their interconversion and intramolecular electrocyclization with applications in chiral separation, sensors, membranes, molecular machines, [6] the discovery of liquid crystals based on conformational isomerism: polyethers, poly(vinyl ether)s, macrocyclics, covalent and supramolecular dendrimers [7] [8] [9] the discovery of self-assembling dendrons, dendrimers and dendronized polymers; and the creation of helical rod-like and spherical viruses mimics. He generated the first organic Frank-Kasper phases and quasicrystals. [9] [10] [11] [12] He revealed double-helices disregarding chirality and deracemization in crystal state, designed the sequence-rearrangement concept to transform dynamic racemic (atactic) into homochiral (isotactic) supramolecular polymers [13] and demonstrated acceleration of self-assembly and disassembly by fluorine and fluorous phase. [8] His discovery of self-interrupted and self-accelerated iterative organic synthesis, polymerizations and living polymerizations produced the first monodisperse polymers by noniterative synthesis. [14] More recently, he uncovered biological membrane mimics from Janus dendrimers, glycodendrimers and ionizable dendrimers; determined they self-assemble into monodisperse artificial cell-like mimics, co-assemble with bacterial and human cells, and generate one component mRNA delivery systems for virus vaccines and drugs. [15] [16] [17] He is also known for the methodologies he developed for organic, macromolecular and supramolecular synthesis: replacement of Pd with Ni in cross-coupling reactions, [18] the concepts of mixed-ligands and catalytic solvents, phase-transfer catalyzed living condensation polymerization, new mechanisms for living polymerization of acetylenes, single-electron-transfer mediated organic and polymerization reactions including living polymerizations. [19] [20] Percec discovered that the one-component multifunctional sequence-defined amphiphilic Janus dendrimer is an efficient delivery system for mRNA. Designed and synthesized several libraries containing sequence-defined multifunctional ionizable amphiphilic Janus dendrimer (IAJD) by an accelerated modular-orthogonal methodology. Demonstrated they co-assemble with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology. These sequence-defined IAJDs and DNPs are being employed to elucidate the mechanisms of encapsulation and release of mRNA from supramolecular virus-like assemblies and for the production of vaccines and drugs. [21] [22] [23]

Awards and achievements

Percec is the author of more than 800 scientific articles, 20 books and special issues and listed as inventor of at least 80 patents. Percec presented over 1200 endowed, plenary and invited lectures. He has served as the Editor of Journal of Polymer Science: Part A: Polymer Chemistry, Advances in Polymer Science and Book Series “Liquid Crystals”. He serves on Editorial and Advisory Scientific Boards of 24 International Journals, and of the advisory boards of many Academic and Industrial Institutions. Percec organized numerous National and International Symposia including Gordon Conferences, and IUPAC meetings. In 2018, Percec was listed as "Global Highly Cited Researches" by Clarivate Analytics for world-class researches and their exceptional research performance based on multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Sciences. In 2016, 2015, and 2014 he was listed as "One of The World's Most Influential Scientific Minds of our Time" by Thomson Reuters. Percec delivered over 1400 plenary endowed lectures including: the Raychem Lecturer, Chemistry Department, University of California, Berkeley, CA (1996); The 4th Aggarwal Lecturer in Polymer Science, Chemistry Department, Cornell University, NY (1997); The Inaugural Woodward Lecturer "Frontiers in Chemical Sciences", Harvard University (2004); the 7th Rohm and Haas Lecture at the University of California, Berkeley (2005); the Lecturer of the Swiss Chemical Society (2008); Invited Lecture at Kekule Institute of Organic Chemistry and Biochemistry at the University of Bonn (2010); [24] the Inaugural Kavli Foundation Innovations in Chemistry Lecture and Award, [25] American Chemical Society (2011); The 8th International Dendrimer Symposium (2013); [26] the Inaugural Aldrich lecture at Massachusetts Institute of Technology (2015); Ben-Gurion University of the Negev, Israel, Department of Chemistry and the Faculty of Natural Science's Distinguished Scientist Visitor and Lecturers (2016); IVA 100: Centennial Jubilee Workshop of the Royal Swedish Academy of Engineering Sciences (2019). [27] Percec is an Honorary Foreign Member of the Romanian Academy (1993), Doctor Honoris Causa of University of Athens (Greece), Polytechnic University Iasi (Romania) since 2007 and of Polytechnic University, Bucharest (2016). He is an Honorary Member of the Israel Chemical Society (2009) and of the Romanian Society of Chemistry and "Petru Poni" Medal of the Romanian Society of Chemistry (2014). Percec educated over 300 PhD and postdoctoral students with more than 70 of them being in faculty positions. [28]

Awards

Related Research Articles

Supramolecular chemistry refers to the branch of chemistry concerning chemical systems composed of a discrete number of molecules. The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the energy parameters of the component. While traditional chemistry concentrates on the covalent bond, supramolecular chemistry examines the weaker and reversible non-covalent interactions between molecules. These forces include hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi–pi interactions and electrostatic effects.

<span class="mw-page-title-main">Polycatenane</span> Mechanically interlocked molecular architecture

A polycatenane is a chemical substance that, like polymers, is chemically constituted by a large number of units. These units are made up of concatenated rings into a chain-like structure.

<span class="mw-page-title-main">Dendrimer</span> Highly ordered, branched polymeric molecule

Dendrimers are highly ordered, branched polymeric molecules. Synonymous terms for dendrimer include arborols and cascade molecules. Typically, dendrimers are symmetric about the core, and often adopt a spherical three-dimensional morphology. The word dendron is also encountered frequently. A dendron usually contains a single chemically addressable group called the focal point or core. The difference between dendrons and dendrimers is illustrated in the top figure, but the terms are typically encountered interchangeably.

<span class="mw-page-title-main">Supramolecular assembly</span> Complex of molecules non-covalently bound together

In chemistry, a supramolecular assembly is a structure consisting of molecules held together by noncovalent bonds. While a supramolecular assembly can be simply composed of two molecules, or a defined number of stoichiometrically interacting molecules within a quaternary complex, it is more often used to denote larger complexes composed of indefinite numbers of molecules that form sphere-, rod-, or sheet-like species. Colloids, liquid crystals, biomolecular condensates, micelles, liposomes and biological membranes are examples of supramolecular assemblies, and their realm of study is known as supramolecular chemistry. The dimensions of supramolecular assemblies can range from nanometers to micrometers. Thus they allow access to nanoscale objects using a bottom-up approach in far fewer steps than a single molecule of similar dimensions.

<span class="mw-page-title-main">Corannulene</span> Chemical compound

Corannulene is a polycyclic aromatic hydrocarbon with chemical formula C20H10. The molecule consists of a cyclopentane ring fused with 5 benzene rings, so another name for it is [5]circulene. It is of scientific interest because it is a geodesic polyarene and can be considered a fragment of buckminsterfullerene. Due to this connection and also its bowl shape, corannulene is also known as a buckybowl. Buckybowls are fragments of buckyballs. Corannulene exhibits a bowl-to-bowl inversion with an inversion barrier of 10.2 kcal/mol (42.7 kJ/mol) at −64 °C.

In polymer chemistry and materials science, the term "polymer" refers to large molecules whose structure is composed of multiple repeating units. Supramolecular polymers are a new category of polymers that can potentially be used for material applications beyond the limits of conventional polymers. By definition, supramolecular polymers are polymeric arrays of monomeric units that are connected by reversible and highly directional secondary interactions–that is, non-covalent bonds. These non-covalent interactions include van der Waals interactions, hydrogen bonding, Coulomb or ionic interactions, π-π stacking, metal coordination, halogen bonding, chalcogen bonding, and host–guest interaction. The direction and strength of the interactions are precisely tuned so that the array of molecules behaves as a polymer in dilute and concentrated solution, as well as in the bulk.

<span class="mw-page-title-main">Janus particles</span> Type of nanoparticle or microparticle

Janus particles are special types of nanoparticles or microparticles whose surfaces have two or more distinct physical properties. This unique surface of Janus particles allows two different types of chemistry to occur on the same particle. The simplest case of a Janus particle is achieved by dividing the particle into two distinct parts, each of them either made of a different material, or bearing different functional groups. For example, a Janus particle may have one half of its surface composed of hydrophilic groups and the other half hydrophobic groups, the particles might have two surfaces of different color, fluorescence, or magnetic properties. This gives these particles unique properties related to their asymmetric structure and/or functionalization.

<span class="mw-page-title-main">Takuzo Aida</span> Japanese polymer chemist

Takuzo Aida is a polymer chemist known for his work in the fields of supramolecular chemistry, materials chemistry and polymer chemistry. Aida, who is the Deputy Director for the RIKEN Center for Emergent Matter Science (CEMS) and a Distinguished University Professor at the University of Tokyo, has made pioneering contributions to the initiation, fundamental progress, and conceptual expansion of supramolecular polymerization. Aida has also been a leader and advocate for addressing critical environmental issues caused by plastic waste and microplastics in the oceans, soil, and food supply, through the development of dynamic, responsive, healable, reorganizable, and adaptive supramolecular polymers and related soft materials.

Jeremy Keith Morris Sanders is a British chemist and Emeritus Professor in the Department of Chemistry at the University of Cambridge. He is also Editor-in-Chief of Royal Society Open Science. He is known for his contributions to many fields including NMR spectroscopy and supramolecular chemistry. He served as the Pro-Vice-Chancellor for Institutional Affairs at the University of Cambridge, 2011–2015.

<span class="mw-page-title-main">Bert Meijer</span> Dutch organic chemist

Egbert (Bert) Willem Meijer is a Dutch organic chemist, known for his work in the fields of supramolecular chemistry, materials chemistry and polymer chemistry. Meijer, who is distinguished professor of Molecular Sciences at Eindhoven University of Technology (TU/e) and Academy Professor of the Royal Netherlands Academy of Arts and Sciences, is considered one of the founders of the field of supramolecular polymer chemistry. Meijer is a prolific author, sought-after academic lecturer and recipient of multiple awards in the fields of organic and polymer chemistry.

Ayyappanpillai Ajayaghosh is a research scientist/academician in the domain of interdisciplinary chemistry, and the former Director of the National Institute for Interdisciplinary Science and Technology. He is known for his studies on supramolecular assemblies, organogels, photoresponsive materials, chemosensory and security materials systems and is an elected fellow of all the three major Indian science academies viz. the National Academy of Sciences, India, Indian National Science Academy and the Indian Academy of Sciences as well as The World Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Chemical Sciences in 2007. He is the first chemist to receive the Infosys Science Prize for physical sciences, awarded by the Infosys Science Foundation. He received the TWAS Prize of The World Academy of Sciences in 2013 and the Goyal prize in 2019.

<span class="mw-page-title-main">Kim Kimoon</span> South Korean chemist

Kim Kimoon is a South Korean chemist and professor in the Department of Chemistry at Pohang University of Science and Technology (POSTECH). He is the first and current director of the Center for Self-assembly and Complexity at the Institute for Basic Science. Kim has authored or coauthored 300 papers which have been cited more than 30,000 times and he holds a number of patents. His work has been published in Nature, Nature Chemistry, Angewandte Chemie, and JACS, among others. He has been a Clarivate Analytics Highly Cited Researcher in the field of chemistry in 2014, 2015, 2016.

<span class="mw-page-title-main">Supramolecular catalysis</span> Field of chemistry

Supramolecular catalysis is not a well-defined field but it generally refers to an application of supramolecular chemistry, especially molecular recognition and guest binding, toward catalysis. This field was originally inspired by enzymatic system which, unlike classical organic chemistry reactions, utilizes non-covalent interactions such as hydrogen bonding, cation-pi interaction, and hydrophobic forces to dramatically accelerate rate of reaction and/or allow highly selective reactions to occur. Because enzymes are structurally complex and difficult to modify, supramolecular catalysts offer a simpler model for studying factors involved in catalytic efficiency of the enzyme. Another goal that motivates this field is the development of efficient and practical catalysts that may or may not have an enzyme equivalent in nature.

<span class="mw-page-title-main">Mark M. Green</span> American chemist

Mark Mordecai Green is an American chemist, writer and professor of chemical and biomolecular engineering at the New York University Tandon School of Engineering. He is best known for his extensive work on an aspect of stereochemistry involved in cooperative chirality and also for his book Organic Chemistry Principles in Context: A Story Telling Historical Approach, which can be used in teaching organic chemistry in an unprecedented way.

<span class="mw-page-title-main">Ben Feringa</span> Dutch Nobel laureate in chemistry

Bernard Lucas Feringa is a Dutch synthetic organic chemist, specializing in molecular nanotechnology and homogeneous catalysis. He is the Jacobus van 't Hoff Distinguished Professor of Molecular Sciences, at the Stratingh Institute for Chemistry, University of Groningen, Netherlands, and an Academy Professor of the Royal Netherlands Academy of Arts and Sciences. He was awarded the 2016 Nobel Prize in Chemistry, together with Sir J. Fraser Stoddart and Jean-Pierre Sauvage, "for the design and synthesis of molecular machines".

William Dichtel is the Robert L. Letsinger Professor of Chemistry at Northwestern University and a 2015 MacArthur Fellow who has helped pioneer the development of porous polymers known as covalent organic frameworks. Dichtel was awarded a Guggenheim Fellowship in 2018. In 2020, Dichtel was selected as the 2020 Laureate in Chemistry of the Blavatnik Awards for Young Scientists. He also founded Cylopure, a university spin-off that seeks to bring to market water filtration with cyclodextrin polymers.

<span class="mw-page-title-main">Subi Jacob George</span> Indian organic chemist

Subi Jacob George is an Indian organic chemist, known for his work in the fields of supramolecular chemistry, materials chemistry, and polymer chemistry. His research interests includes organic and supramolecular synthesis, functional organic materials, supramolecular polymers, chiral amplification, hybrid materials, and optoelectronic materials.

<span class="mw-page-title-main">Macromolecular cages</span>

Macromolecular cages have three dimensional chambers surrounded by a molecular framework. Macromolecular cage architectures come in various sizes ranging from 1-50 nm and have varying topologies as well as functions. They can be synthesized through covalent bonding or self-assembly through non-covalent interactions. Most macromolecular cages that are formed through self-assembly are sensitive to pH, temperature, and solvent polarity.

Sankaran "Thai" Thayumanavan is an Indian-American chemist, who is currently a Distinguished Professor of Chemistry at the University of Massachusetts Amherst. He is known for his work in polymer chemistry. He is a Fellow of the American Association for the Advancement of Science (AAAS).

<span class="mw-page-title-main">Roeland Nolte</span> Dutch chemist (1944–2024)

Roeland J. M. Nolte was a Dutch chemist, known for his work in the fields of organic chemistry, biochemistry, polymer chemistry, and supramolecular chemistry. He was an emeritus Royal Netherlands Academy of Arts and Sciences professor and an emeritus professor of organic chemistry at Radboud University in Nijmegen, The Netherlands. Until his death, he held a special chair, i.e. professor of molecular nanotechnology, at Radboud University. Nolte was considered to be one of the pioneers of the field of supramolecular chemistry, which encompasses the design and synthesis of new chemical structures from low molecular weight compounds and biopolymers using non-covalent interactions. He published many studies on supramolecular assembly and biomimetic catalysts, which find applications in the field of nanomaterials and medicine.

References

  1. ↑ "Professor Virgil Percec – Percec Research Laboratory". web.sas.upenn.edu.
  2. ↑ "The Molecular Architect" (PDF). p. 11.
  3. ↑ "Home - Institute of Macromolecular Chemistry "Petru Poni" Iasi". icmpp.ro.
  4. ↑ "Ivona Percec, MD, PhD - Penn Medicine Cosmetic Services". www.pennmedicine.org.
  5. ↑ "Ivona Percec | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania".
  6. ↑ Simionescu, C. I.; Percec, V.; Dumitrescu, Svetlana (May 24, 1977). "Polymerization of acetylenic derivatives. XXX. Isomers of polyphenylacetylene". Journal of Polymer Science: Polymer Chemistry Edition. 15 (10): 2497–2509. Bibcode:1977JPoSA..15.2497S. doi: 10.1002/pol.1977.170151018 . S2CID   95698354 – via Wiley Online Library.
  7. ↑ Hudson, S. D.; Jung, H.-T.; Percec, V.; Cho, W.-D.; Johansson, G.; Ungar, G.; Balagurusamy, V. S. K. (October 17, 1997). "Direct Visualization of Individual Cylindrical and Spherical Supramolecular Dendrimers". Science. 278 (5337): 449–452. Bibcode:1997Sci...278..449H. doi:10.1126/science.278.5337.449 – via science.sciencemag.org.
  8. 1 2 "Archived copy". Archived from the original on 2021-05-24. Retrieved 2021-05-24.{{cite web}}: CS1 maint: archived copy as title (link)
  9. 1 2 Percec, V.; Ahn, C.-H.; Ungar, G.; Yeardley, D. J. P.; Möller, M.; Sheiko, S. S. (January 24, 1998). "Controlling polymer shape through the self-assembly of dendritic side-groups". Nature. 391 (6663): 161–164. Bibcode:1998Natur.391..161P. doi:10.1038/34384. S2CID   4321044 – via www.nature.com.
  10. ↑ Ungar, Goran; Liu, Yongsong; Zeng, Xiangbing; Percec, Virgil; Cho, Wook-Dong (February 21, 2003). "Giant Supramolecular Liquid Crystal Lattice". Science. 299 (5610): 1208–1211. Bibcode:2003Sci...299.1208U. doi:10.1126/science.1078849. PMID   12595686. S2CID   31427370 – via science.sciencemag.org.
  11. ↑ Zeng, Xiangbing; Ungar, Goran; Liu, Yongsong; Percec, Virgil; Dulcey, Andrés E.; Hobbs, Jamie K. (March 24, 2004). "Supramolecular dendritic liquid quasicrystals". Nature. 428 (6979): 157–160. doi:10.1038/nature02368. PMID   15014524. S2CID   4429689 – via www.nature.com.
  12. ↑ Percec, Virgil; Dulcey, Andrés E.; Balagurusamy, Venkatachalapathy S. K.; Miura, Yoshiko; Smidrkal, Jan; Peterca, Mihai; Nummelin, Sami; Edlund, Ulrica; Hudson, Steven D.; Heiney, Paul A.; Duan, Hu; Magonov, Sergei N.; Vinogradov, Sergei A. (August 24, 2004). "Self-assembly of amphiphilic dendritic dipeptides into helical pores". Nature. 430 (7001): 764–768. Bibcode:2004Natur.430..764P. doi:10.1038/nature02770. PMID   15306805. S2CID   4405030 – via www.nature.com.
  13. ↑ Percec, Virgil; Imam, Mohammad R.; Peterca, Mihai; Wilson, Daniela A.; Graf, Robert; Spiess, Hans W.; Balagurusamy, Venkatachalapathy S. K.; Heiney, Paul A. (March 23, 2009). "Self-Assembly of Dendronized Triphenylenes into Helical Pyramidal Columns and Chiral Spheres". Journal of the American Chemical Society. 131 (22): 7662–7677. doi:10.1021/ja8094944. PMID   19309145.
  14. ↑ Holerca, Marian N.; Peterca, Mihai; Partridge, Benjamin E.; Xiao, Qi; Lligadas, Gerard; Monteiro, Michael J.; Percec, Virgil (August 20, 2020). "Monodisperse Macromolecules by Self-Interrupted Living Polymerization". Journal of the American Chemical Society. 142 (36): 15265–15270. doi:10.1021/jacs.0c07912. PMID   32815364. S2CID   221202107.
  15. ↑ Percec, Virgil; Wilson, Daniela A.; Leowanawat, Pawaret; Wilson, Christopher J.; Hughes, Andrew D.; Kaucher, Mark S.; Hammer, Daniel A.; Levine, Dalia H.; Kim, Anthony J.; Bates, Frank S.; Davis, Kevin P.; Lodge, Timothy P.; Klein, Michael L.; DeVane, Russell H.; Aqad, Emad; Rosen, Brad M.; Argintaru, Andreea O.; Sienkowska, Monika J.; Rissanen, Kari; Nummelin, Sami; Ropponen, Jarmo (May 21, 2010). "Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures". Science. 328 (5981): 1009–1014. Bibcode:2010Sci...328.1009P. doi:10.1126/science.1185547. PMID   20489021. S2CID   5387095 – via science.sciencemag.org.
  16. ↑ Rosen, Brad M.; Wilson, Christopher J.; Wilson, Daniela A.; Peterca, Mihai; Imam, Mohammad R.; Percec, Virgil (2009). "Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems". Chemical Reviews. 109 (11): 6275–6540. doi:10.1021/cr900157q. PMID   19877614.
  17. ↑ Percec, V.; Glodde, M.; Bera, T. K.; Miura, Y.; Shiyanovskaya, I.; Singer, K. D.; Balagurusamy, V. S. K.; Heiney, P. A.; Schnell, I.; Rapp, A.; Spiess, H.-W.; Hudson, S. D.; Duan, H. (2002). "Self-organization of supramolecular helical dendrimers into complex electronic materials". Nature. 419 (6905): 384–387. Bibcode:2002Natur.417..384P. doi:10.1038/nature01072. PMID   12352988. S2CID   1708646.
  18. ↑ Rosen, Brad M.; Quasdorf, Kyle W.; Wilson, Daniella A.; Zhang, Na; Resmerita, Ana-Maria; Garg, Neil K.; Percec, Virgil (2011). "Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds". Chemical Reviews. 111 (3): 1346–1416. doi:10.1021/cr100259t. PMC   3055945 . PMID   21133429.
  19. ↑ Rosen, Brad M.; Quasdorf, Kyle W.; Wilson, Daniella A.; Zhang, Na; Resmerita, Ana-Maria; Garg, Neil K.; Percec, Virgil (March 9, 2011). "Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds". Chemical Reviews. 111 (3): 1346–1416. doi:10.1021/cr100259t. PMC   3055945 . PMID   21133429.
  20. ↑ Percec, Virgil; Guliashvili, Tamaz; Ladislaw, Janine S.; Wistrand, Anna; Stjerndahl, Anna; Sienkowska, Monika J.; Monteiro, Michael J.; Sahoo, Sangrama (November 24, 2006). "Ultrafast Synthesis of Ultrahigh Molar Mass Polymers by Metal-Catalyzed Living Radical Polymerization of Acrylates, Methacrylates, and Vinyl Chloride Mediated by SET at 25 °C". Journal of the American Chemical Society. 128 (43): 14156–14165. doi:10.1021/ja065484z. PMID   17061900.
  21. ↑ Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Huang, Ning; Xiao, Qi; Ona, Nathan; Liu, Matthew; Shahnawaz, Hamna; Ni, Houping; Kim, Kyunghee; Billingsley, Margaret M. (July 29, 2021). "One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA". Journal of the American Chemical Society. 143 (31): 12315–12327. doi:10.1021/jacs.1c05813. ISSN   0002-7863. PMID   34324336. S2CID   236516292.
  22. ↑ Zhang, Dapeng; Atochina-Vasserman, Elena N.; Lu, Juncheng; Maurya, Devendra S.; Xiao, Qi; Liu, Matthew; Adamson, Jasper; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew (2022-03-23). "The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity". Journal of the American Chemical Society. 144 (11): 4746–4753. doi:10.1021/jacs.2c00273. ISSN   0002-7863. PMID   35263098. S2CID   247360314.
  23. ↑ Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Liu, Matthew; Xiao, Qi; Lu, Juncheng; Lauri, George; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew (2021-11-03). "Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers". Journal of the American Chemical Society. 143 (43): 17975–17982. doi:10.1021/jacs.1c09585. ISSN   0002-7863. PMID   34672554. S2CID   239457963.
  24. ↑ Archived at Ghostarchive and the Wayback Machine : Bioinspired synthesis of complex functional systems. YouTube .
  25. ↑ "ACS Kavli lectures highlight the biggest, the smallest, and the most complex" . Retrieved 2023-12-24.
  26. ↑ "Highlights of the 8th International Dendrimer Symposium" . Retrieved 2023-12-24.
  27. ↑ "Jubileumsseminarium: Materialens betydelse i samhället". youtube.com (in Swedish).
  28. ↑ "Group Members – Percec Research Laboratory".
  29. ↑ "Virgil Percec Elected to Royal Swedish Academy of Engineering Sciences, IVA | Department of Chemistry".
  30. ↑ "OFI - Österreichisches Forschungs- und Prüfinstitut". www.ofi.at.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.