David A. Hafler | |
|---|---|
 Hafler in November 2020 | |
| Born | 1952 (age 71–72) New York City, U.S. |
| Occupation | Neurologist |
| Known for | His work in the fields of immunity, genetics and multiple sclerosis |
David A. Hafler (born 1952) is an American neurologist. He is the Edgerly Professor and chairman of the department of Neurology at the Yale School of Medicine, where he works on immunity, genetics, and multiple sclerosis. In 2018, he was elected to the National Academy of Medicine.
Hafler was born in 1952 in New York. He became interested in immunology at a young age and began doing research in the field as a high school student. [1] In 1974 he graduated from Emory University in Atlanta, Georgia with a combined Bachelor of Science in chemistry and Master of Science in biochemistry. His master's thesis was on fragments of myelin basic protein. [2]
In 1978, he received his MD degree from the University of Miami School of Medicine in Miami, Florida. He was a medical intern from 1978–1979 at the Johns Hopkins Hospital in Baltimore, Maryland. From 1979 to 1982, he was a resident in neurology at the New York Hospital-Cornell Medical Center and Memorial Sloan Kettering Cancer Institute in New York City. In 1982, he was a guest investigator in the laboratory of the immunologist Henry G. Kunkel at Rockefeller University. [2]
From 1982 to 1984, he was a fellow in neurology and immunology at Harvard Medical School in Boston, Massachusetts. He was one of the first post-doctoral fellows of Howard L. Weiner, and began to work in his lab on multiple sclerosis. In 1984, he joined the faculty of Harvard Medical School in the department of Neurology. He stayed on in Weiner's laboratory, becoming a principal investigator. [2]
In 1998, Hafler and Weiner co-founded a private biotech company called Autoimmune Inc., a biopharmaceutical company developing orally administered pharmaceutical products for the treatment of autoimmune and other cell-mediated inflammatory diseases and conditions. The Company's products, which induce tissue-specific immunosuppression without toxicity, are based upon the principles of oral tolerance. [3] The company went public in 1993 with Henri Termeer and others on the Board of Directors. [4]
In 2000, he was appointed to an endowed professorship and became the Breakstone Professor of Neurology at Harvard. [2]
In 2009, Hafler and his laboratory moved to Yale Medical School in New Haven, Connecticut, where he became the Glaser Professor and chairman of the department of Neurology. [2] He was awarded the John Dystel Prize for Multiple Sclerosis Research in 2010 by the American Academy of Neurology and National Multiple Sclerosis Society. It was awarded "for fundamental discoveries related to MS in fields such as immunology and genetics, and for bringing clinical importance to basic science findings." [5]
In 2015, Hafler was appointed to the newly created Edgerly Professorship in Neurology at Yale. This endowed professorship was provided by William S. and Lois Stiles Edgerly who had long supported research in multiple sclerosis. [6] In 2018 he was elected to membership in the National Academy of Medicine with the citation "For seminal discoveries defining the pathogenesis of multiple sclerosis (MS), including identification of autoreactive T cells and mechanisms that underlie their dysregulation, and the discovery of susceptibility genes that lead to MS." [7]
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Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage. The underlying cause is currently unknown. Current research in neuropathology, neuroimmunology, neurobiology, and neuroimaging, together with clinical neurology, provide support for the notion that MS is not a single disease but rather a spectrum.
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Alan J. Thompson, MD, FMedSci, FRCP, FRCPI, is Dean of the Faculty of Brain Sciences at UCL; Pro-Provost for London at UCL; Garfield Weston Professor of Clinical Neurology and Neurorehabilitation at the UCL Queen Square Institute of Neurology. He is also a consultant neurologist at the University College London NHS Hospitals Foundation Trust working at the National Hospital for Neurology and Neurosurgery. He is Editor-in-Chief for Multiple Sclerosis Journal.
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| Authority control databases: Academics |
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