Deltex e3 ubiquitin ligase 3

DTX3
Identifiers
Aliases	DTX3 , RNF154, deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3
External IDs	OMIM: 613142; MGI: 2135752; HomoloGene: 12754; GeneCards: DTX3; OMA:DTX3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,609,804 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,195,728 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right frontal lobe; ; right uterine tube; ; endothelial cell; ; left ovary; ; body of uterus; ; right ovary; ; anterior cingulate cortex; ; nucleus accumbens;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; ventricular zone; ; habenula; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; metal ion binding ; transferase activity ; zinc ion binding ;
Cellular component	cytoplasm ;
Biological process	Notch signaling pathway ; protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	196403
	80904
	ENSG00000178498
	ENSMUSG00000040415
	Q8N9I9
	Q80V91
	NM_001286245 ; NM_001286246 ; NM_178502
	NM_030714 ; NM_001368332
	NP_001273174 ; NP_001273175 ; NP_848597
	NP_109639 ; NP_001355261
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2024

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.^[5] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.^[6] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.^[6]

Function

DTX3 functions as an E3 ubiquitin ligase.^[7] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.^[6]

Related Research Articles

ITCH is a HECT domain–containing E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. The ITCH gene is located on chromosome 20 in humans. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.

Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.

RanBP-type and C3HC4-type zinc finger-containing protein 1 is a protein that in humans is encoded by the RBCK1 gene.

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. In human it has 1606 amino acids and isoelectric point of 5.18.

Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene. It functions as an ubiquitin ligase (E3), and is over-expressed in chemotherapy-resistant lymphomas. It is a member of the DTX family of proteins. Among other roles it has a function in DNA damage repair.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178498 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040415 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Deltex E3 ubiquitin ligase 3" . Retrieved 2016-09-26.
1 2 3 Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi: 10.3390/cells12131680 . ISSN 2073-4409. PMC 10340142 . PMID 37443713.
↑ Takeyama, Kunihiko; Aguiar, Ricardo C. T.; Gu, Liqun; He, Chunyan; Freeman, Gordon J.; Kutok, Jeffery L.; Aster, Jon C.; Shipp, Margaret A. (2003-06-13). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937. doi: 10.1074/jbc.M301157200 . ISSN 0021-9258. PMID 12670957.

Deltex e3 ubiquitin ligase 3

Contents

Function

Related Research Articles

References

Further reading