Derlin-2

DERL2
Identifiers
Aliases	DERL2 , F-LAN-1, F-LANa, FLANa, CGI-101, DERtrin-2, derlin 2, derlin-2
External IDs	OMIM: 610304; MGI: 2151483; HomoloGene: 9356; GeneCards: DERL2; OMA:DERL2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 5,471,254 bp [1] End 5,486,811 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B4|11 43.21 cM Start 70,897,990 bp [2] End 70,910,667 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis body of pancreas Achilles tendon right lobe of liver parotid gland mucosa of transverse colon olfactory zone of nasal mucosa right adrenal gland granulocyte Top expressed in cumulus cell left lobe of liver seminal vesicula lacrimal gland decidua right lung lobe stroma of bone marrow islet of Langerhans right kidney yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding serine-type endopeptidase activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane late endosome early endosome endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum quality control compartment signal recognition particle receptor complex signal recognition particle Biological process endoplasmic reticulum unfolded protein response positive regulation of cell growth retrograde protein transport, ER to cytosol response to unfolded protein negative regulation of retrograde protein transport, ER to cytosol positive regulation of cell population proliferation ubiquitin-dependent ERAD pathway suckling behavior endoplasmic reticulum mannose trimming proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51009 116891 Ensembl ENSG00000072849 ENSMUSG00000018442 UniProt Q9GZP9 Q8BNI4 RefSeq (mRNA) NM_001304777 NM_001304779 NM_016041 NM_001291146 NM_001291147 NM_001291148 NM_033562 RefSeq (protein) NP_001291706 NP_001291708 NP_057125 NP_001278075 NP_001278076 NP_001278077 NP_291040 Location (UCSC) Chr 17: 5.47 – 5.49 Mb Chr 11: 70.9 – 70.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Derlin-2 is a protein that in humans is encoded by the DERL2 gene. ^{[5] [6] [7]}

See also

• Derlin-1
• Derlin-3

References

1. GRCh38: Ensembl release 89: ENSG00000072849 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018442 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
6. Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID   11500051.
7. "Entrez Gene: DERL2 Der1-like domain family, member 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lilley BN, Ploegh HL (2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID   15215855. S2CID   29483256.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lilley BN, Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–301. Bibcode:2005PNAS..10214296L. doi: 10.1073/pnas.0505014102 . PMC   1242303 . PMID   16186509.
• Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC   2063648 . PMID   16449189.
• Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts". J. Cell Biol. 172 (3): 423–32. doi:10.1083/jcb.200505175. PMC   2063651 . PMID   16449192.
• Maas C, Tagnaouti N, Loebrich S, et al. (2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin". J. Cell Biol. 172 (3): 441–51. doi:10.1083/jcb.200506066. PMC   2063653 . PMID   16449194.
• Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL (2006). "Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection". J. Virol. 80 (17): 8739–44. doi:10.1128/JVI.00791-06. PMC   1563856 . PMID   16912321.