Derlin-2 is a protein that in humans is encoded by the DERL2 gene. [5] [6] [7]
Derlin-2 is a protein that in humans is encoded by the DERL2 gene. [5] [6] [7]
Calnexin (CNX) is a 67kDa integral protein of the endoplasmic reticulum (ER). It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short, acidic cytoplasmic tail.
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.
Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.
Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.
Selenoprotein S, also known as SELS, is a human gene.
E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene.
Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene.
Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.
Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a membrane protein that in humans is encoded by the DERL1 gene. Derlin-1 is located in the membrane of the endoplasmic reticulum (ER) and is involved in retrotranslocation of specific misfolded proteins and in ER stress. Derlin-1 is widely expressed in thyroid, fat, bone marrow and many other tissues. The protein belongs to the Derlin-family proteins consisting of derlin-1, derlin-2 and derlin-3 that are components in the endoplasmic reticulum-associated protein degradation (ERAD) pathway. The derlins mediate degradation of misfolded lumenal proteins within ER, and are named ‘der’ for their ‘Degradation in the ER’. Derlin-1 is a mammalian homologue of the yeast DER1 protein, a protein involved in the yeast ERAD pathway. Moreover, derlin-1 is a member of the rhomboid-like clan of polytopic membrane proteins.
Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.
Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene.
BET1 homolog is a protein that in humans is encoded by the BET1 gene.
Conserved oligomeric Golgi complex subunit 8 is a protein that in humans is encoded by the COG8 gene.
Stress-associated endoplasmic reticulum protein 1 is a protein that in humans is encoded by the SERP1 gene.
Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.
Derlin-3 is a protein that in humans is encoded by the DERL3 gene.
Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.
ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.
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