Dextran 70

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Dextran 70
Clinical data
Trade names RescueFlow, others
AHFS/Drugs.com Monograph
Routes of
administration
intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
UNII
Chemical and physical data
Molar mass 70,000 Da

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume. [1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available. [2] However, it does not carry oxygen. [2]

Common side effects include vomiting, fever, and joint pains. [2] Other side effects include allergic reactions and poor blood clotting. [1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder. [2] It is not recommended during pregnancy. [3] It works by pulling fluid from the extravascular space into the blood vessels. [2]

Dextran 70 was approved for medical use in 1947. [4] It is on the World Health Organization's List of Essential Medicines. [5] It comes in either sodium chloride solution or glucose solution. [2]

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References

  1. 1 2 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl: 10665/44053 . ISBN   9789241547659.
  2. 1 2 3 4 5 6 "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
  3. British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN   9780857111562.
  4. BeMiller JN, Whistler RL (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN   9780080926544. Archived from the original on 2017-01-03.
  5. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771 . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.