Docking protein 6

DOK6
Identifiers
Aliases	DOK6 , DOK5L, HsT3226, docking protein 6
External IDs	OMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6
Gene location (Human)
Chr.	Chromosome 18 (human)
End	69,849,087 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	89,787,652 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; pons; ; endothelial cell; ; middle temporal gyrus; ; ganglionic eminence; ; entorhinal cortex; ; Brodmann area 23; ; spinal ganglia; ; ventral tegmental area; ; superior frontal gyrus;
	Top expressed in
	hippocampus proper; ; superior frontal gyrus; ; olfactory bulb; ; hypothalamus; ; cerebellar cortex; ; ganglionic eminence; ; mesencephalon; ; neural tube; ; spinal ganglia; ; trigeminal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytosol ;
Biological process	axon guidance ;
	Sources:Amigo / QuickGO
Orthologs
	220164
	623279
	ENSG00000206052
	ENSMUSG00000073514
	Q6PKX4
	Q2MHE5
	NM_152721
	NM_001039173
	NP_689934
	NP_001034262
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. ^[5]

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

Related Research Articles

The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene. In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled.

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.

Olfactory receptor 6F1 is a protein that in humans is encoded by the OR6F1 gene.

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.

GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene.

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene. Adipolin is an adipokine.

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene.

F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000206052 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073514 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Docking protein 6" . Retrieved 2017-02-01.

Docking protein 6

Contents

Function

Related Research Articles

References

Further reading