Duncan Leitch (neurobiologist)

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Duncan Bernardo Leitch is a neurobiologist working at the University of California San Francisco. He was born in Memphis, Tennessee, in 1984. Leitch attended Vanderbilt University, where he gained recognition for his work on the integumentary sensory organs in crocodilians.

He has published many articles on star-nosed moles, naked mole-rats, and other insectivores.

In 2012, Kenneth C. Catania and Leitch published a study on the somatosensory sensation of crocodilians, including American alligators and Nile crocodiles in the Journal of Experimental Biology. This garnered public attention in the journals Nature , Science , National Geographic , and international news media. In this work, he and Catania describe the physiological response properties of neurons in the trigeminal ganglion, showing that the sense of touch in crocodilians surpasses those of human fingertips, despite being a thickly-scaled surface.

More recently, Leitch has led breakthrough studies in the field of electroreception, whereby he and his team characterized the molecular basis for electrosensation by sharks and skates [1] [2]

Related Research Articles

<span class="mw-page-title-main">Crocodile</span> Subfamily of large reptilian carnivores

Crocodiles or true crocodiles are large semiaquatic reptiles that live throughout the tropics in Africa, Asia, the Americas and Australia. The term crocodile is sometimes used even more loosely to include all extant members of the order Crocodilia, which includes the alligators and caimans, the gharial and false gharial among other extinct taxa.

<span class="mw-page-title-main">Crocodilia</span> Order of mostly large, predatory, semiaquatic reptiles

Crocodilia is an order of mostly large, predatory, semiaquatic reptiles, known as crocodilians. They first appeared 95 million years ago in the Late Cretaceous period and are the closest living relatives of birds, as the two groups are the only known survivors of the Archosauria. Members of the order's total group, the clade Pseudosuchia, appeared about 250 million years ago in the Early Triassic period, and diversified during the Mesozoic era. The order Crocodilia includes the true crocodiles, the alligators and caimans, and the gharial and false gharial. Although the term 'crocodiles' is sometimes used to refer to all of these, crocodilians is a less ambiguous vernacular term for members of this group.

<span class="mw-page-title-main">Gnathostomata</span> Infraphylum of vertebrates

Gnathostomata are the jawed vertebrates. Gnathostome diversity comprises roughly 60,000 species, which accounts for 99% of all living vertebrates, including humans. In addition to opposing jaws, living gnathostomes have true teeth, paired appendages, the elastomeric protein of elastin, and a horizontal semicircular canal of the inner ear, along with physiological and cellular anatomical characters such as the myelin sheaths of neurons, and an adaptive immune system that has the discrete lymphoid organs of spleen and thymus, and uses V(D)J recombination to create antigen recognition sites, rather than using genetic recombination in the variable lymphocyte receptor gene.

<span class="mw-page-title-main">Alligator</span> Crocodilian in the genus Alligator of the family Alligatoridae

An alligator is a large reptile in the Crocodilia order in the genus Alligator of the family Alligatoridae. The two extant species are the American alligator and the Chinese alligator. Additionally, several extinct species of alligator are known from fossil remains. Alligators first appeared during the Oligocene epoch about 37 million years ago.

<span class="mw-page-title-main">Electroreception and electrogenesis</span> Detection of weak electric fields, via specialized sense organs and brain structures

Electroreception and electrogenesis are the closely-related biological abilities to perceive electrical stimuli and to generate electric fields. Both are used to locate prey; stronger electric discharges are used in a few groups of fishes to stun prey. The capabilities are found almost exclusively in aquatic or amphibious animals, since water is a much better conductor of electricity than air. In passive electrolocation, objects such as prey are detected by sensing the electric fields they create. In active electrolocation, fish generate a weak electric field and sense the different distortions of that field created by objects that conduct or resist electricity. Active electrolocation is practised by two groups of weakly electric fish, the Gymnotiformes (knifefishes) and the Mormyridae (elephantfishes), and by Gymnarchus niloticus, the African knifefish. An electric fish generates an electric field using an electric organ, modified from muscles in its tail. The field is called weak if it is only enough to detect prey, and strong if it is powerful enough to stun or kill. The field may be in brief pulses, as in the elephantfishes, or a continuous wave, as in the knifefishes. Some strongly electric fish, such as the electric eel, locate prey by generating a weak electric field, and then discharge their electric organs strongly to stun the prey; other strongly electric fish such as the electric ray electrolocate passively. The stargazers are unique in being strongly electric but not using electrolocation.

<span class="mw-page-title-main">Nile crocodile</span> Reptile of Africa

The Nile crocodile is a large crocodilian native to freshwater habitats in Africa, where it is present in 26 countries. It is widely distributed throughout sub-Saharan Africa, occurring mostly in the central, eastern, and southern regions of the continent, and lives in different types of aquatic environments such as lakes, rivers, swamps, and marshlands. In West Africa, it occurs along with two other crocodilians. Although capable of living in saline environments, this species is rarely found in saltwater, but occasionally inhabits deltas and brackish lakes. The range of this species once stretched northward throughout the Nile, as far north as the Nile Delta. On average, the adult male Nile crocodile is between 2.94 and 4.4 m in length and weighs 225 to 414.5 kg including stomach stones. However, specimens exceeding 6.1 m (20 ft) in length and weighing up to 1,089 kg (2,401 lb) have been recorded. It is the largest freshwater predator in Africa, and may be considered the second-largest extant reptile in the world, after the saltwater crocodile. Size is sexually dimorphic, with females usually about 30% smaller than males. The crocodile has thick, scaly, heavily armoured skin.

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<span class="mw-page-title-main">Star-nosed mole</span> Species of Mole

The star-nosed mole is a small mole found in moist, low areas in the northern parts of North America. It is the only extant member of the tribe Condylurini and genus Condylura, and it has more than 25,000 minute sensory receptors in touch organs, known as Eimer's organs, with which this hamster-sized mole feels its way around. With the help of its Eimer's organs, it may be perfectly poised to detect seismic wave vibrations.

<span class="mw-page-title-main">Archosauriformes</span> Clade of reptiles

Archosauriformes is a clade of diapsid reptiles that developed from archosauromorph ancestors some time in the Latest Permian. It was defined by Jacques Gauthier (1994) as the clade stemming from the last common ancestor of Proterosuchidae and Archosauria ; Phil Senter (2005) defined it as the most exclusive clade containing Proterosuchus and Archosauria.

<span class="mw-page-title-main">False gharial</span> Species of crocodilian

The false gharial, also known by the names Malayan gharial,Sunda gharial and tomistoma, is native to Peninsular Malaysia, Borneo, Sumatra and Java. This freshwater crocodilian in the family Gavialidae is listed as Vulnerable on the IUCN Red List, as the global population is estimated at around 2,500 to 10,000 mature individuals.

<span class="mw-page-title-main">Ampullae of Lorenzini</span> Sensory organs in some fish that detect electrical fields

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Nitrifying bacteria are chemolithotrophic organisms that include species of genera such as Nitrosomonas, Nitrosococcus, Nitrobacter, Nitrospina, Nitrospira and Nitrococcus. These bacteria get their energy from the oxidation of inorganic nitrogen compounds. Types include ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB). Many species of nitrifying bacteria have complex internal membrane systems that are the location for key enzymes in nitrification: ammonia monooxygenase, hydroxylamine oxidoreductase, and nitrite oxidoreductase.

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Kenneth C. Catania is a biologist and neuroscientist teaching and conducting research at Vanderbilt University in Nashville, Tennessee. As an undergraduate, Catania worked as a research assistant at the National Zoo in Washington D.C. while attending the University of Maryland, College Park. In 1989, he received a BS in zoology from the University of Maryland. He received a master's degree (1992) and Ph.D. (1994) in neurosciences from the University of California, San Diego, working with Glenn Northcutt. He did his post-doctoral work with Jon Kaas at Vanderbilt University before joining the Vanderbilt Biological Sciences faculty in 2000 where he is currently a Stevenson Professor of Biological Sciences.

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<span class="mw-page-title-main">David Julius</span> American physiologist and Nobel laureate 2021

David Jay Julius is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California, San Francisco.

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<span class="mw-page-title-main">Christopher G. Tate</span>

Christopher G. TateFRS is an English membrane protein biochemist and molecular biologist who works at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. Tate is known for his contributions to the understanding of G protein-coupled receptors.

<span class="mw-page-title-main">Kiyoshi Nagai</span> Japanese structural biologist (1949–2019)

Kiyoshi Nagai was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He was known for his work on the mechanism of RNA splicing and structures of the spliceosome.

<span class="mw-page-title-main">Pangalloanserae</span> Clade of birds

Pangalloanserae is a clade of birds defined in a 2001 study by Jacques Gauthier and Kevin de Queiroz as "most inclusive clade containing Galloanserae but not Neoaves". It contains crown Galloanserae as well as all stem-galloanserans.

References

  1. Bellono, Nicholas W.; Leitch, Duncan B.; Julius, David (June 2018). "Molecular tuning of electroreception in sharks and skates". Nature. 558 (7708): 122–126. Bibcode:2018Natur.558..122B. doi:10.1038/s41586-018-0160-9. ISSN   1476-4687. PMC   6101975 . PMID   29849147.
  2. Bellono, Nicholas W.; Leitch, Duncan B.; Julius, David (March 16, 2017). "Molecular basis of ancestral vertebrate electroreception". Nature. 543 (7645): 391–396. Bibcode:2017Natur.543..391B. doi:10.1038/nature21401. ISSN   1476-4687. PMC   5354974 . PMID   28264196.