EAF1

EAF1
Identifiers
Aliases	EAF1 , ELL associated factor 1
External IDs	OMIM: 608315; MGI: 1921677; HomoloGene: 12561; GeneCards: EAF1; OMA:EAF1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.1 Start 15,427,598 bp [1] End 15,450,635 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 B Start 31,216,356 bp [2] End 31,231,815 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid islet of Langerhans decidua monocyte secondary oocyte lower lobe of lung palpebral conjunctiva pancreatic epithelial cell epithelium of nasopharynx prefrontal cortex Top expressed in epithelium of lens tail of embryo olfactory epithelium decidua primitive streak superior cervical ganglion gastrula thymus genital tubercle endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Cajal body nuclear speck transcription elongation factor complex super elongation complex intracellular membrane-bounded organelle intercellular bridge nucleus nucleoplasm nuclear body Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85403 74427 Ensembl ENSG00000144597 ENSMUSG00000021890 UniProt Q96JC9 Q9D4C5 RefSeq (mRNA) NM_033083 NM_028932 RefSeq (protein) NP_149074 NP_083208 Location (UCSC) Chr 3: 15.43 – 15.45 Mb Chr 14: 31.22 – 31.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene. ^{[5] [6]} It is part of the EAF family of proteins.

References

1. GRCh38: Ensembl release 89: ENSG00000144597 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021890 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. doi:10.1182/blood.V98.1.201. PMID   11418481. S2CID   2577367.
6. "Entrez Gene: EAF1 ELL associated factor 1".

Further reading

• Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. doi:10.1091/mbc.E02-07-0394. PMC   153119 . PMID   12686606.
• Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. Bibcode:2005PNAS..10210094K. doi: 10.1073/pnas.0503017102 . PMC   1177379 . PMID   16006523.
• Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID   16114057. S2CID   32749490.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC   1989770 . PMID   17395368.