EAF2

EAF2
Identifiers
Aliases	EAF2 , BM040, TRAITS, U19, ELL associated factor 2
External IDs	OMIM: 607659; MGI: 2146616; HomoloGene: 10208; GeneCards: EAF2; OMA:EAF2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.33 Start 121,835,183 bp [1] End 121,886,526 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B3 Start 36,613,246 bp [2] End 36,695,365 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell monocyte lymph node trabecular bone granulocyte appendix kidney tubule epithelium of nasopharynx rectum spleen Top expressed in female urethra right kidney proximal tubule lacrimal gland epithelium of urethra epithelium of female urethra seminal vesicula pelvic part of vagina male urethra epithelium of male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding Cellular component nuclear speck transcription elongation factor complex super elongation complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell growth negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of transcription by RNA polymerase II transcription, DNA-templated apoptotic process transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55840 106389 Ensembl ENSG00000145088 ENSMUSG00000022838 UniProt Q96CJ1 Q91ZD6 RefSeq (mRNA) NM_018456 NM_001320041 NM_001113401 NM_001113405 NM_134111 NM_001358102 RefSeq (protein) NP_001306970 NP_060926 NP_001106872 NP_001106876 NP_598872 NP_001345031 Location (UCSC) Chr 3: 121.84 – 121.89 Mb Chr 16: 36.61 – 36.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene. ^{[5] [6] [7]} It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000145088 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022838 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi: 10.1182/blood-2002-06-1664 . PMID   12446457.
6. Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID   12907652.
7. "Entrez Gene: EAF2 ELL associated factor 2".
8. Simone, Federico; Luo, Roger T.; Polak, Paul E.; Kaberlein, Joseph J.; Thirman, Michael J. (2003-03-15). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties" . Blood. 101 (6): 2355–2362. doi:10.1182/blood-2002-06-1664. ISSN   0006-4971.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi: 10.1093/jb/mvg065 . PMID   12761297.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. Bibcode:2005PNAS..10210094K. doi: 10.1073/pnas.0503017102 . PMC   1177379 . PMID   16006523.
• Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID   16114057. S2CID   32749490.
• Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC   1989770 . PMID   17395368.