ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene. [5] [6] [7] It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins. [8]
ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene. [5] [6] [7] It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins. [8]
The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL–ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.
Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.
Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.
Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.
CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic.
RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.
FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.
Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.
Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.
Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.
Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.
General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.
Transcription elongation factor SPT6 is a protein that in humans is encoded by the SUPT6H gene.
Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene.
ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene. It is part of the EAF family of proteins.
In molecular biology, the EAF family of proteins act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II transcriptional elongation factors. EAF proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. ELL and EAF1 are components of Cajal bodies, which have a role in leukemogenesis. EAF1 also has the capacity to interact with ELL1 and ELL2. The N terminus of approx 120 of EAF1 has a region of high serine, aspartic acid, and glutamic acid residues.
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