Protein ECT2 is a protein that in humans is encoded by the ECT2 gene. [4] [5] [6]
Protein ECT2 is a protein that in humans is encoded by the ECT2 gene. [4] [5] [6]
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [6]
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.
Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. The importance of PKCζ in the creation and maintenance of long-term potentiation was first described by Todd Sacktor and his colleagues at the SUNY Downstate Medical Center in 1993.
Mitogen-activated protein kinase 1, also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.
G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.
Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.
LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.
Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.
Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.
Kinesin-like protein KIF23 is a protein that in humans is encoded by the KIF23 gene.
RhoG is a small monomeric GTP-binding protein, and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins and is encoded by the gene RHOG.
Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.
Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene.
Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.
Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ANLN gene in humans and the scraps gene in Drosophila encode Anillin. In 1989, anillin was first isolated in embryos of Drosophila melanogaster. It was identified as an F-actin binding protein. Six years later, the anillin gene was cloned from cDNA originating from a Drosophila ovary. Staining with anti-anillin antibody showed the anillin localizes to the nucleus during interphase and to the contractile ring during cytokinesis. These observations agree with further research that found anillin in high concentrations near the cleavage furrow coinciding with RhoA, a key regulator of contractile ring formation.
Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.
Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Centralspindlin is a motor complex implicated in cell division. It contributes to virtually every step in cytokinesis, It is highly conserved in animal cells as a component of the spindle midzone and midbody. Centralspindlin is required for the assembly of the mitotic spindle as well as for microtubule bundling and anchoring of midbody microtubules to the plasma membrane. This complex is also implicated in tethering the spindle apparatus to the plasma membrane during cytokinesis This interaction permits cleavage furrow ingression. In addition, centralspindlin's interaction with the ESCRT III allows for abscission to occur.
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