EDEM2

EDEM2
Identifiers
Aliases	EDEM2 , C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2
External IDs	OMIM: 610302 MGI: 1915540 HomoloGene: 10075 GeneCards: EDEM2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 35,115,364 bp [1] End 35,147,336 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 155,543,597 bp [2] End 155,571,395 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right lobe of liver islet of Langerhans right adrenal gland body of pancreas left adrenal gland anterior pituitary spleen blood upper lobe of left lung Top expressed in lacrimal gland islet of Langerhans salivary gland parotid gland crypt of lieberkuhn of small intestine pyloric antrum seminal vesicula epithelium of stomach submandibular gland left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment Biological process endoplasmic reticulum unfolded protein response mannose trimming involved in glycoprotein ERAD pathway N-glycan processing positive regulation of retrograde protein transport, ER to cytosol response to unfolded protein ubiquitin-dependent glycoprotein ERAD pathway trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55741 108687 Ensembl ENSG00000088298 ENSMUSG00000038312 UniProt Q9BV94 Q8BJT9 RefSeq (mRNA) NM_001145025 NM_018217 NM_145537 RefSeq (protein) NP_001138497 NP_060687 NP_663512 Location (UCSC) Chr 20: 35.12 – 35.15 Mb Chr 2: 155.54 – 155.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000088298 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038312 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID   15537790.
6. Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi: 10.1074/jbc.C400534200 . PMID   15579471.
7. "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.