EDF1

EDF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X57
Identifiers
Aliases	EDF1 , EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs	OMIM: 605107; MGI: 1891227; HomoloGene: 2809; GeneCards: EDF1; OMA:EDF1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 136,862,119 bp [1] End 136,866,308 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 25,447,859 bp [2] End 25,452,094 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland anterior pituitary body of pancreas right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon duodenum right hemisphere of cerebellum jejunal mucosa body of stomach Top expressed in Paneth cell facial motor nucleus motor neuron fossa endothelial cell of lymphatic vessel condyle transitional epithelium of urinary bladder duodenum right kidney left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity transcription coactivator activity calmodulin binding histone acetyltransferase activity protein binding RNA binding TFIID-class transcription factor complex binding Cellular component cytoplasm transcription factor TFIID complex intracellular anatomical structure nucleolus extracellular exosome nucleus cytosol Biological process cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated regulation of lipid metabolic process endothelial cell differentiation positive regulation of DNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8721 59022 Ensembl ENSG00000107223 ENSMUSG00000015092 UniProt O60869 Q9JMG1 RefSeq (mRNA) NM_153200 NM_001281297 NM_001281298 NM_001281299 NM_003792 NM_021519 RefSeq (protein) NP_001268226 NP_001268227 NP_001268228 NP_003783 NP_694880 NP_067494 Location (UCSC) Chr 9: 136.86 – 136.87 Mb Chr 2: 25.45 – 25.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the nuclear reactor EDF1, see Chinon Nuclear Power Plant.

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene. ^{[5] [6] [7]}

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. ^[7]

Interactions

EDF1 has been shown to interact with:

• Liver X receptor alpha, ^[8]
• Peroxisome proliferator-activated receptor gamma, ^[8] and
• TATA binding protein. ^{[8] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000107223 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015092 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi: 10.1074/jbc.273.47.31119 . PMID   9813014.
6. Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMC   11146030 . PMID   15112053. S2CID   861006.
7. "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
8. Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi: 10.1210/mend.16.6.0843 . PMID   12040021.
9. Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi: 10.1074/jbc.M001928200 . PMID   10816571.
10. Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi: 10.1074/jbc.274.48.34196 . PMID   10567391.

Further reading

• Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. doi:10.1128/mcb.14.5.3013. PMC   358669 . PMID   8164657.
• Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells. 4 (7): 415–24. doi: 10.1046/j.1365-2443.1999.00267.x . PMID   10469174. S2CID   17825943.
• Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi: 10.1074/jbc.M001928200 . PMID   10816571.
• Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi: 10.1210/mend.16.6.0843 . PMID   12040021.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene. 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID   16567061.