EDF1

EDF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X57
Identifiers
Aliases	EDF1 , EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs	OMIM: 605107; MGI: 1891227; HomoloGene: 2809; GeneCards: EDF1; OMA:EDF1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,866,308 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,452,094 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; anterior pituitary; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; duodenum; ; right hemisphere of cerebellum; ; jejunal mucosa; ; body of stomach;
	Top expressed in
	Paneth cell; ; facial motor nucleus; ; motor neuron; ; fossa; ; endothelial cell of lymphatic vessel; ; condyle; ; transitional epithelium of urinary bladder; ; duodenum; ; right kidney; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity ; sequence-specific DNA binding ; DNA binding ; DNA-binding transcription factor activity ; transcription coactivator activity ; calmodulin binding ; histone acetyltransferase activity ; protein binding ; RNA binding ; TFIID-class transcription factor complex binding ;
Cellular component	cytoplasm ; transcription factor TFIID complex ; intracellular anatomical structure ; nucleolus ; extracellular exosome ; nucleus ; cytosol ;
Biological process	cell differentiation ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; multicellular organism development ; positive regulation of transcription, DNA-templated ; regulation of lipid metabolic process ; endothelial cell differentiation ; positive regulation of DNA binding ;
	Sources:Amigo / QuickGO
Orthologs
	8721
	59022
	ENSG00000107223
	ENSMUSG00000015092
	O60869
	Q9JMG1
	NM_153200 ; NM_001281297 ; NM_001281298 ; NM_001281299 ; NM_003792 Contents Function ; Interactions ; References ; Further reading ;
	NM_021519
	NP_001268226 ; NP_001268227 ; NP_001268228 ; NP_003783 ; NP_694880
	NP_067494
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2024

For the nuclear reactor EDF1, see Chinon Nuclear Power Plant

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.^[5]^[6]^[7]

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.^[7]

Interactions

EDF1 has been shown to interact with:

Related Research Articles

The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.

AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Serum response factor, also known as SRF, is a transcription factor protein.

COUP-TFII, also known as NR2F2 is a protein that in humans is encoded by the NR2F2 gene. The COUP acronym stands for chicken ovalbumin upstream promoter.

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence.

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107223 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015092 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi: 10.1074/jbc.273.47.31119 . PMID 9813014.
↑ Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMC 11146030 . PMID 15112053. S2CID 861006.
1 2 "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
1 2 3 Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi: 10.1210/mend.16.6.0843 . PMID 12040021.
↑ Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi: 10.1074/jbc.M001928200 . PMID 10816571.
↑ Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi: 10.1074/jbc.274.48.34196 . PMID 10567391.

EDF1

Contents

Function

Interactions

Related Research Articles

References

Further reading