EFCAB6

EFCAB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WLZ, 5D67
Identifiers
Aliases	EFCAB6 , DJBP, HSCBCIP1, dJ185D5.1, EF-hand calcium binding domain 6
External IDs	MGI: 1924877; HomoloGene: 11259; GeneCards: EFCAB6; OMA:EFCAB6 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2-q13.31 Start 43,528,744 bp [1] End 43,812,337 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1- E2 Start 83,750,913 bp [2] End 83,949,580 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm buccal mucosa cell right uterine tube bronchial epithelial cell oocyte testicle olfactory zone of nasal mucosa gonad Top expressed in spermatid seminiferous tubule spermatocyte zygote primary oocyte secondary oocyte muscle of thigh temporal muscle cornea skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64800 77627 Ensembl ENSG00000186976 ENSMUSG00000022441 UniProt Q5THR3 Q6P1E8 RefSeq (mRNA) NM_022785 NM_198856 NM_001161628 NM_001161629 NM_029946 RefSeq (protein) NP_073622 NP_942153 NP_001155100 NP_001155101 NP_084222 Location (UCSC) Chr 22: 43.53 – 43.81 Mb Chr 15: 83.75 – 83.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene. ^{[5] [6] [7]}

Interactions

EFCAB6 has been shown to interact with PARK7 ^[6] and Androgen receptor. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186976 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022441 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (Mar 2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi: 10.1093/dnares/8.1.1 . PMID   11258795.
6. Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Mar 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Mol Cancer Res. 1 (4): 247–61. PMID   12612053.
7. "Entrez Gene: FLJ23588 CAP-binding protein complex interacting protein 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.