EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene [5] belonging to the EHD protein family.
EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene [5] belonging to the EHD protein family.
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. [5]
EHD1 has been shown to interact with Insulin-like growth factor 1 receptor [6] and SNAP29. [6]
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.
Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.
Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.
Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.
Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.
Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.
Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.
Epsin-2 is a protein that in humans is encoded by the EPN2 gene.
RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.
Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.
EH-domain containing 2, also known as EHD2, is a human gene belonging to the EHD protein family.
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
The EHD protein family is a relatively small group of proteins which have been shown to play a role in several physiological functions, the most notable being the regulation of endocytotic vesicles. This family is recognized by its highly conserved EH domain, a structural motif that has been shown to facilitate specificity and interaction between protein and ligand. The four mammalian EHD proteins that have been classified are: EHD1, EHD2, EHD3, and EHD4.
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