EID1

EID1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NUF
Identifiers
Aliases	EID1 , C15orf3, CRI1, EID-1, IRO45620, PTD014, RBP21, PNAS-22, EP300 interacting inhibitor of differentiation 1
External IDs	OMIM: 605894 MGI: 1889651 HomoloGene: 49376 GeneCards: EID1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	48,880,173 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	125,516,705 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; germinal epithelium; ; right ventricle; ; internal globus pallidus; ; seminal vesicula; ; superficial temporal artery; ; ganglionic eminence; ; retinal pigment epithelium; ; myocardium; ; prefrontal cortex;
	Top expressed in
	barrel cortex; ; dorsomedial hypothalamic nucleus; ; median eminence; ; fossa; ; atrium; ; habenula; ; condyle; ; subiculum; ; suprachiasmatic nucleus; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; histone acetyltransferase binding ; transcription corepressor activity ; histone acetyltransferase regulator activity ;
Cellular component	cytoplasm ; nucleus ; nucleoplasm ; cytoplasmic ribonucleoprotein granule ;
Biological process	cell cycle ; cell differentiation ; negative regulation of transcription, DNA-templated ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; regulation of histone acetylation ; regulation of cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	23741
	58521
	ENSG00000255302
	ENSMUSG00000091337
	Q9Y6B2
	Q9DCR4
	NM_014335
	NM_025613
	NP_055150
	NP_079889
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 28, 2023

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.^[5]^[6]^[7]

Interactions

EID1 has been shown to interact with EP300 ^[6]^[8] and Retinoblastoma protein.^[6]^[8]

Related Research Articles

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.

Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

HMG-box transcription factor 1, also known as HBP1, is a human protein.

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene.

Protein CREG1 is a protein that in humans is encoded by the CREG1 gene.

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000255302 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091337 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624. S2CID 27139235.
1 2 3 MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545 . PMID 11073990.
↑ "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".
1 2 Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544 . PMID 11073989.

Ghosh AK, Varga J (2007). "The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis". J. Cell. Physiol. 213 (3): 663–71. doi: 10.1002/jcp.21162 . PMID 17559085. S2CID 41744258.
Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. doi: 10.1016/S1097-2765(00)80056-8 . PMID 9660940.
Miyake S, Sellers WR, Safran M, et al. (2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. PMC 86544 . PMID 11073989.
Wen H, Ao S (2001). "Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein". Gene. 263 (1–2): 85–92. doi:10.1016/S0378-1119(00)00585-0. PMID 11223246.
Båvner A, Johansson L, Toresson G, et al. (2002). "A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP". EMBO Rep. 3 (5): 478–84. doi:10.1093/embo-reports/kvf087. PMC 1084100 . PMID 11964378.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ledl A, Schmidt D, Müller S (2005). "Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor". Oncogene. 24 (23): 3810–8. doi: 10.1038/sj.onc.1208539 . PMID 15806172.
Krützfeldt M, Ellis M, Weekes DB, et al. (2005). "Selective ablation of retinoblastoma protein function by the RET finger protein". Mol. Cell. 18 (2): 213–24. doi: 10.1016/j.molcel.2005.03.009 . PMID 15837424.
Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623–35. doi: 10.1016/j.molcel.2005.05.012 . PMID 15949438.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000255302 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091337 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10828624-5] Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624. S2CID 27139235.

[pmid11073990-6] 1 2 3 MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545 . PMID 11073990.

[entrez-7] "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".

[pmid11073989-8] 1 2 Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544 . PMID 11073989.

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EID1

Contents

Interactions

Related Research Articles

References

Further reading