ELAC1

ELAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZWF
Identifiers
Aliases	ELAC1 , D29, elaC ribonuclease Z 1
External IDs	OMIM: 608079; MGI: 1890495; HomoloGene: 10272; GeneCards: ELAC1; OMA:ELAC1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.2 Start 50,967,991 bp [1] End 50,988,121 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E2 Start 73,868,109 bp [2] End 73,887,550 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon gonad right adrenal gland right lobe of thyroid gland body of pancreas left adrenal gland testicle right adrenal cortex left adrenal cortex Top expressed in retinal pigment epithelium lacrimal gland dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus ciliary body substantia nigra central gray substance of midbrain median eminence arcuate nucleus lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity endonuclease activity 3'-tRNA processing endoribonuclease activity hydrolase activity metal ion binding endoribonuclease activity, producing 5'-phosphomonoesters Cellular component cytoplasm cytosol nucleus Biological process tRNA 3'-trailer cleavage RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing tRNA 3'-trailer cleavage, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55520 114615 Ensembl ENSG00000141642 ENSMUSG00000036941 UniProt Q9H777 Q8VEB6 RefSeq (mRNA) NM_018696 NM_053255 RefSeq (protein) NP_061166 NP_444485 Location (UCSC) Chr 18: 50.97 – 50.99 Mb Chr 18: 73.87 – 73.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene. ^{[5] [6]}

Function

The enzyme is a phosphodiesterase.

References

1. GRCh38: Ensembl release 89: ENSG00000141642 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036941 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takaku H, Minagawa A, Takagi M, Nashimoto M (Apr 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC   154223 . PMID   12711671.
6. "Entrez Gene: ELAC1 elaC homolog 1 (E. coli)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yanaihara N, Kohno T, Takakura S, et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID   11401430.
• Tavtigian SV, Simard J, Teng DH, et al. (2001). "A candidate prostate cancer susceptibility gene at chromosome 17p". Nat. Genet. 27 (2): 172–80. doi:10.1038/84808. PMID   11175785. S2CID   7889550.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.