ELAV-like protein 2

ELAVL2
Identifiers
Aliases	ELAVL2 , HEL-N1, HELN1, HUB, ELAV like neuron-specific RNA binding protein 2, ELAV like RNA binding protein 2
External IDs	OMIM: 601673; MGI: 1100887; HomoloGene: 20930; GeneCards: ELAVL2; OMA:ELAVL2 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse) [1] Band 4 C5|4 42.36 cM Start 91,250,763 bp [1] End 91,400,785 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in superior cervical ganglion facial motor nucleus Rostral migratory stream mammillary body medial ganglionic eminence medial dorsal nucleus medial vestibular nucleus lateral hypothalamus pontine nuclei dorsomedial hypothalamic nucleus BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA 3'-UTR binding nucleic acid binding RNA binding Cellular component nucleoplasm Biological process regulation of transcription, DNA-templated mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1993 15569 Ensembl ENSG00000107105 ENSMUSG00000008489 UniProt Q12926 Q60899 RefSeq (mRNA) NM_001171195 NM_001171197 NM_004432 NM_001177883 NM_010486 NM_207685 NM_207686 NM_001347149 NM_001357188 NM_001357189 RefSeq (protein) NP_001164666 NP_001164668 NP_004423 NP_001338384 NP_001338385 NP_001338386 NP_001338387 NP_001338388 NP_001338389 NP_001338390 NP_001338391 NP_001338392 NP_001338393 NP_001338394 NP_001338395 NP_001338396 NP_001338397 NP_001338398 NP_001338399 NP_001338400 NP_001338401 NP_001338402 NP_001338403 NP_001338404 NP_001338405 NP_001338406 NP_001338407 NP_001171354 NP_001334078 NP_034616 NP_997568 NP_997569 NP_001344117 NP_001344118 NP_001361165 NP_001361166 NP_001361167 NP_001361625 Location (UCSC) n/a Chr 4: 91.25 – 91.4 Mb PubMed search [2] [3]
Wikidata
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ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene. ^{[4] [5]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000008489 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics. 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID   8812435.
5. "Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Further reading

• Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. Bibcode:1994PNAS...9111207G. doi: 10.1073/pnas.91.23.11207 . PMC   45196 . PMID   7972035.
• King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor". J. Neurosci. 14 (4): 1943–52. doi:10.1523/JNEUROSCI.14-04-01943.1994. PMC   6577146 . PMID   8158249.
• Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation". J. Cell Sci. 109 (3): 579–89. doi:10.1242/jcs.109.3.579. PMID   8907704.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC   85909 . PMID   10848602.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation". J. Biol. Chem. 280 (13): 12690–9. doi: 10.1074/jbc.M411119200 . PMID   15671036.