EMCN

EMCN
Identifiers
Aliases	EMCN , EMCN2, MUC14, endomucin
External IDs	OMIM: 608350; MGI: 1891716; HomoloGene: 9438; GeneCards: EMCN; OMA:EMCN - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q24 Start 100,395,341 bp [1] End 100,880,126 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G3 Start 137,046,828 bp [2] End 137,137,946 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon lower lobe of lung parietal pleura skin of hip renal medulla right lobe of thyroid gland visceral pleura human kidney right lung gallbladder Top expressed in left lung lobe adrenal gland genital tubercle atrioventricular valve right kidney atrium cardiac muscle tissue of left ventricle interventricular septum right lung human kidney More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 51705 59308 Ensembl ENSG00000164035 ENSMUSG00000054690 UniProt Q9ULC0 Q9R0H2 RefSeq (mRNA) NM_001159694 NM_016242 NM_001163522 NM_016885 RefSeq (protein) NP_001153166 NP_057326 NP_001156994 NP_058581 Location (UCSC) Chr 4: 100.4 – 100.88 Mb Chr 3: 137.05 – 137.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endomucin is a protein that in humans is encoded by the EMCN gene. ^{[5] [6] [7]} Endomucin is a marker for endothelial cells ^[8] and hematopoietic stem cells. ^[9]

Function

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. ^{[5] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000164035 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054690 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi: 10.1016/S0014-5793(01)02520-0 . PMID   11418125. S2CID   23615506.
6. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID   11594763.
7. "Entrez Gene: EMCN endomucin".
8. Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288 (1): 129–136. doi:10.1006/bbrc.2001.5737. PMID   11594763.
9. Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC   2213340 . PMID   16314436.

Further reading

• Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi: 10.1007/s00262-003-0471-y . PMC   11032928 . PMID   14722670. S2CID   10785466.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (May 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC   1850881 . PMID   12000719.
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC   2375403 . PMID   12087473.
• Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (December 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi: 10.1046/j.1523-1747.2002.19647.x . PMID   12485444.
• Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (September 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology . 16 (9): 1265–74. doi: 10.1093/intimm/dxh128 . PMID   15249540.
• Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances . 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC   6039657 . PMID   29986855.