EMCN | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | EMCN , EMCN2, MUC14, endomucin | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Endomucin is a protein that in humans is encoded by the EMCN gene. [5] [6] [7] Endomucin is a marker for endothelial cells [8] and hematopoietic stem cells. [9]
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. [5] [7]
CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. L-selectin plays an important role in both the innate and adaptive immune responses by facilitating leukocyte-endothelial cell adhesion events. These tethering interactions are essential for the trafficking of monocytes and neutrophils into inflamed tissue as well as the homing of lymphocytes to secondary lymphoid organs. L-selectin is also expressed by lymphoid primed hematopoietic stem cells and may participate in the migration of these stem cells to the primary lymphoid organs. In addition to its function in the immune response, L-selectin is expressed on embryonic cells and facilitates the attachment of the blastocyst to the endometrial endothelium during human embryo implantation.
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.
Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.
Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene.
Anthrax toxin receptor 1 is a protein that in humans is encoded by the ANTXR1 gene. Its molecular weight is predicted as about 63kDa.
E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.
Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.
Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene.
Septin-7 is a protein that in humans is encoded by the SEPT7 gene.
Stomatin-like protein 2 is a protein that in humans is encoded by the STOML2 gene.
Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.
Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.
Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.
Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.
The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.
Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.
Protein CWC15 homolog is a protein that in humans is encoded by the CWC15 gene.