ENPP3

Last updated
ENPP3
Identifiers
Aliases ENPP3 , B10, CD203c, NPP3, PD-IBETA, PDNP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
External IDs OMIM: 602182; MGI: 2143702; HomoloGene: 3683; GeneCards: ENPP3; OMA:ENPP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005021

NM_134005
NM_145372

RefSeq (protein)

NP_005012

NP_598766

Location (UCSC) Chr 6: 131.63 – 131.75 Mb Chr 10: 24.65 – 24.72 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is an enzyme that in humans is encoded by the ENPP3 gene. [5] [6]

Contents

Function

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [6]

This protein has also been used in conjunction with CD63 as a marker for activated basophils in the Basophil Activation Test for IgE mediated allergic reactions. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154269 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019989 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jin-Hua P, Goding JW, Nakamura H, Sano K (October 1997). "Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes". Genomics. 45 (2): 412–5. doi:10.1006/geno.1997.4949. PMID   9344668.
  6. 1 2 "Entrez Gene: ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3".
  7. McGowan EC, Saini S (February 2013). "Update on the performance and application of basophil activation tests". Current Allergy and Asthma Reports . 13 (1): 101–9. doi:10.1007/s11882-012-0324-x. PMC   4078398 . PMID   23188565.

Further reading