ENTPD5

ENTPD5
Identifiers
Aliases	ENTPD5 , CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDs	OMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number	3.6.1.42
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.3 Start 73,958,010 bp [1] End 74,019,399 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 D1|12 39.18 cM Start 84,420,631 bp [2] End 84,455,803 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon rectum jejunal mucosa duodenum liver mucosa of transverse colon right lobe of liver human kidney epithelium of colon mucosa of ileum Top expressed in proximal tubule right kidney human kidney left lobe of liver transitional epithelium of urinary bladder olfactory epithelium esophagus right ventricle jejunum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanosine-diphosphatase activity uridine-diphosphatase activity protein binding hydrolase activity nucleoside-diphosphatase activity Cellular component endoplasmic reticulum extracellular region Biological process 'de novo' posttranslational protein folding ATP metabolic process protein glycosylation protein N-linked glycosylation cell population proliferation positive regulation of glycolytic process regulation of phosphatidylinositol 3-kinase signaling nucleobase-containing small molecule catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 957 12499 Ensembl ENSG00000187097 ENSMUSG00000021236 UniProt O75356 Q9WUZ9 RefSeq (mRNA) NM_001249 NM_001321984 NM_001321985 NM_001321986 NM_001321987 NM_001321988 NM_001330189 NM_001382256 NM_001382257 NM_001382258 NM_001382259 NM_001382260 NM_001382262 NM_001382263 NM_001026214 NM_001286049 NM_001286058 NM_007647 RefSeq (protein) NP_001240 NP_001308913 NP_001308914 NP_001308915 NP_001308916 NP_001308917 NP_001317118 NP_001369185 NP_001369186 NP_001369187 NP_001369188 NP_001369189 NP_001369191 NP_001369192 NP_001021385 NP_001272978 NP_001272987 NP_031673 Location (UCSC) Chr 14: 73.96 – 74.02 Mb Chr 12: 84.42 – 84.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene. ^{[5] [6] [7]}

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000187097 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021236 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID   9271669. S2CID   42644202.
6. Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID   9676430.
7. "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5".

Further reading

• Mulero JJ, Yeung G, Nelken ST, Ford JE (1999). "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates". J. Biol. Chem. 274 (29): 20064–7. doi: 10.1074/jbc.274.29.20064 . PMID   10400613.
• Recio JA, Zambrano N, Peña L, et al. (2000). "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells". Mol. Carcinog. 27 (3): 229–36. doi:10.1002/(SICI)1098-2744(200003)27:3<229::AID-MC10>3.0.CO;2-Z. PMID   10708485. S2CID   21222716.
• Mulero JJ, Yeung G, Nelken ST, et al. (2000). "Biochemical characterization of CD39L4". Biochemistry. 39 (42): 12924–8. doi:10.1021/bi000960y. PMID   11041857.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Blánquez MJ, Regadera J, Mariño J, et al. (2003). "Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia". Mol. Carcinog. 35 (4): 186–95. doi: 10.1002/mc.10091 . PMID   12489110. S2CID   24074840.
• Murphy-Piedmonte DM, Crawford PA, Kirley TL (2005). "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase". Biochim. Biophys. Acta. 1747 (2): 251–9. doi:10.1016/j.bbapap.2004.11.017. PMID   15698960.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Regadera J, Blánquez MJ, González-Peramato P, et al. (2006). "PCPH expression is an early event in the development of testicular germ cell tumors". Int. J. Oncol. 28 (3): 595–604. doi: 10.3892/ijo.28.3.595 . PMID   16465363.
• Villar J, Arenas MI, MacCarthy CM, et al. (2007). "PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism". Cancer Res. 67 (22): 10859–68. doi: 10.1158/0008-5472.CAN-07-2041 . PMID   18006831.