EP400

EP400
Identifiers
Aliases	EP400 , CAGH32, P400, TNRC12, E1A binding protein p400
External IDs	OMIM: 606265 MGI: 1276124 HomoloGene: 38779 GeneCards: EP400
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,080,460 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,918,583 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; secondary oocyte; ; internal globus pallidus; ; right uterine tube; ; ganglionic eminence; ; Brodmann area 23; ; endothelial cell; ; nipple; ; pituitary gland; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; secondary oocyte; ; spermatid; ; internal carotid artery; ; thymus; ; yolk sac; ; superior frontal gyrus; ; lip; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; nucleotide binding ; protein antigen binding ; chromatin binding ; protein binding ; ATP binding ; hydrolase activity ; helicase activity ;
Cellular component	NuA4 histone acetyltransferase complex ; nuclear speck ; nucleus ; Swr1 complex ; nucleoplasm ;
Biological process	histone H2A acetylation ; histone H4 acetylation ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	57634
	75560
	ENSG00000183495
	ENSMUSG00000029505
	Q96L91
	Q8CHI8
	NM_015409
	NM_029337 ; NM_173066
	NP_056224
	NP_083613 ; NP_775089
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

E1A-binding protein p400 is a protein that in humans is encoded by the EP400 gene.^[5]^[6]^[7]

Interactions

EP400 has been shown to interact with Transformation/transcription domain-associated protein,^[6] RuvB-like 1 ^[6] and Myc.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183495 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029505 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
1 2 3 4 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (Aug 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi: 10.1016/S0092-8674(01)00450-0 . PMID 11509179. S2CID 15634637.
↑ "Entrez Gene: EP400 E1A binding protein p400".

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID 10819331.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID 11347906.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560 . PMID 14966270.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Chan HM, Narita M, Lowe SW, Livingston DM (2005). "The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway". Genes Dev. 19 (2): 196–201. doi:10.1101/gad.1280205. PMC 545875 . PMID 15655109.
Samuelson AV, Narita M, Chan HM, et al. (2005). "p400 is required for E1A to promote apoptosis". J. Biol. Chem. 280 (23): 21915–23. doi: 10.1074/jbc.M414564200 . PMID 15741165.
Tyteca S, Vandromme M, Legube G, et al. (2006). "Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression". EMBO J. 25 (8): 1680–9. doi:10.1038/sj.emboj.7601066. PMC 1440826 . PMID 16601686.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183495 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029505 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9225980-5] Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.

[pmid11509179-6] 1 2 3 4 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (Aug 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi: 10.1016/S0092-8674(01)00450-0 . PMID 11509179. S2CID 15634637.

[entrez-7] "Entrez Gene: EP400 E1A binding protein p400".

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EP400

Contents

Interactions

Related Research Articles

References

Further reading