EP400

EP400
Identifiers
Aliases	EP400 , CAGH32, P400, TNRC12, E1A binding protein p400
External IDs	OMIM: 606265; MGI: 1276124; HomoloGene: 38779; GeneCards: EP400; OMA:EP400 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.33 Start 131,949,942 bp [1] End 132,080,460 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 110,812,239 bp [2] End 110,918,583 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii sural nerve secondary oocyte ventricular zone internal globus pallidus right uterine tube right hemisphere of cerebellum left ovary testicle right ovary Top expressed in zygote spermatocyte seminiferous tubule tail of embryo ventricular zone genital tubercle Rostral migratory stream secondary oocyte spermatid neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding protein antigen binding chromatin binding protein binding ATP binding hydrolase activity helicase activity Cellular component NuA4 histone acetyltransferase complex nuclear speck nucleus Swr1 complex nucleoplasm Biological process histone H2A acetylation histone H4 acetylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57634 75560 Ensembl ENSG00000183495 ENSMUSG00000029505 UniProt Q96L91 Q8CHI8 RefSeq (mRNA) NM_015409 NM_029337 NM_173066 RefSeq (protein) NP_056224 NP_083613 NP_775089 Location (UCSC) Chr 12: 131.95 – 132.08 Mb Chr 5: 110.81 – 110.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E1A-binding protein p400 is a protein that in humans is encoded by the EP400 gene. ^{[5] [6] [7]}

Interactions

EP400 has been shown to interact with Transformation/transcription domain-associated protein, ^[6] RuvB-like 1 ^[6] and Myc. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000183495 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID   9225980. S2CID   25999127.
6. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (Aug 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi: 10.1016/S0092-8674(01)00450-0 . PMID   11509179. S2CID   15634637.
7. "Entrez Gene: EP400 E1A binding protein p400".

Further reading

• Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID   15196461.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID   12963728.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC   350560 . PMID   14966270.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chan HM, Narita M, Lowe SW, Livingston DM (2005). "The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway". Genes Dev. 19 (2): 196–201. doi:10.1101/gad.1280205. PMC   545875 . PMID   15655109.
• Samuelson AV, Narita M, Chan HM, et al. (2005). "p400 is required for E1A to promote apoptosis". J. Biol. Chem. 280 (23): 21915–23. doi: 10.1074/jbc.M414564200 . PMID   15741165.
• Tyteca S, Vandromme M, Legube G, et al. (2006). "Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression". EMBO J. 25 (8): 1680–9. doi:10.1038/sj.emboj.7601066. PMC   1440826 . PMID   16601686.