EPC1

EPC1
Identifiers
Aliases	EPC1 , Epl1, enhancer of polycomb homolog 1
External IDs	OMIM: 610999 MGI: 1278322 HomoloGene: 32627 GeneCards: EPC1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	32,378,798 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	6,516,108 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; secondary oocyte; ; pancreatic epithelial cell; ; endothelial cell; ; spongy bone; ; tibialis anterior muscle; ; lactiferous duct; ; pancreatic ductal cell; ; caput epididymis; ; thymus;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; cumulus cell; ; fossa; ; conjunctival fornix; ; condyle; ; external carotid artery; ; utricle; ; cerebellar vermis; ; retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone acetyltransferase activity ; protein binding ;
Cellular component	Piccolo NuA4 histone acetyltransferase complex ; nuclear membrane ; nucleus ; NuA4 histone acetyltransferase complex ; nucleoplasm ;
Biological process	vascular associated smooth muscle cell differentiation ; regulation of transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; histone H4 acetylation ; positive regulation of transcription by RNA polymerase II ; histone H2A acetylation ; regulation of transcription by RNA polymerase II ; positive regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of growth ; negative regulation of gene expression, epigenetic ; negative regulation of transcription, DNA-templated ; negative regulation of G0 to G1 transition ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	80314
	13831
	ENSG00000120616
	ENSMUSG00000024240
	Q9H2F5
	Q8C9X6
	NM_001272004 ; NM_001272019 ; NM_001282391 ; NM_025209
	NM_001276350 ; NM_007935 ; NM_027497
	NP_001258933 ; NP_001258948 ; NP_001269320 ; NP_079485
	NP_001263279 ; NP_031961 ; NP_081773
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120616 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024240 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shimono Y, Murakami H, Hasegawa Y, Takahashi M (Jan 2001). "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions". J Biol Chem. 275 (50): 39411–9. doi: 10.1074/jbc.M006585200 . PMID 10976108.
↑ "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)".

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi: 10.1093/intimm/9.7.1031 . PMID 9237112.
Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID 12963728.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560 . PMID 14966270.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi: 10.1074/jbc.M412509200 . PMID 15536069.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi: 10.1074/jbc.M500001200 . PMID 15647280.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi: 10.1074/jbc.M611198200 . PMID 17192267.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120616 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024240 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10976108-5] Shimono Y, Murakami H, Hasegawa Y, Takahashi M (Jan 2001). "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions". J Biol Chem. 275 (50): 39411–9. doi: 10.1074/jbc.M006585200 . PMID 10976108.

[entrez-6] "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)".

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EPC1

Related Research Articles

References

Further reading