ERAF

AHSP
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1W09, 1W0A, 1W0B, 1XZY, 1Y01, 1Z8U, 3IA3, 3OVU
Identifiers
Aliases	AHSP , EDRF, ERAF, alpha hemoglobin stabilizing protein
External IDs	OMIM: 605821 HomoloGene: 9605 GeneCards: AHSP
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,528,803 bp
RNA expression pattern
	Top expressed in
	cancellous bone; ; bone marrow cells; ; monocyte; ; blood; ; spleen; ; placenta; ; embryo; ; ganglionic eminence; ; periodontal fiber; ; amniotic fluid;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding ; hemoglobin binding ; protein binding ;
Cellular component	cytoplasm ; hemoglobin complex ;
Biological process	protein stabilization ; protein folding ; erythrocyte differentiation ; hemoglobin metabolic process ; hemopoiesis ;
	Sources:Amigo / QuickGO
Orthologs
	51327
	n/a
	ENSG00000169877
	n/a
	Q9NZD4
	n/a
	NM_016633 ; NM_001318221 ; NM_001318222
	n/a
	NP_001305150 ; NP_001305151 ; NP_057717
	n/a
	Wikidata
View/Edit Human

Last updated October 29, 2022

Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene.^[3]^[4]^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169877 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med. 7 (3): 361–4. doi:10.1038/85515. PMID 11231637. S2CID 11499070.
↑ Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature. 417 (6890): 758–63. Bibcode:2002Natur.417..758K. doi:10.1038/nature00803. PMID 12066189. S2CID 4362675.
↑ "Entrez Gene: ERAF erythroid associated factor".

Florio P, Rossi M, Sigurdardottir M, et al. (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A". Steroids. 68 (10–13): 801–7. doi:10.1016/S0039-128X(03)00137-5. PMID 14667971. S2CID 20953018.
Weiss MJ, Zhou S, Feng L, et al. (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci. 1054: 103–17. doi:10.1196/annals.1345.013. PMID 16339656. S2CID 23597786.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
Gell D, Kong Y, Eaton SA, et al. (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein". J. Biol. Chem. 277 (43): 40602–9. doi: 10.1074/jbc.M206084200 . PMID 12192002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Viprakasit V, Tanphaichitr VS, Chinchang W, et al. (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia". Blood. 103 (9): 3296–9. doi: 10.1182/blood-2003-11-3957 . PMID 14715623.
Baudin-Creuza V, Vasseur-Godbillon C, Pato C, et al. (2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state". J. Biol. Chem. 279 (35): 36530–3. doi: 10.1074/jbc.M405389200 . PMID 15220346.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Gallagher PG, Liem RI, Wong E, et al. (2006). "GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene". J. Biol. Chem. 280 (47): 39016–23. doi: 10.1074/jbc.M506062200 . PMID 16186125.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V, et al. (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone". J. Biol. Chem. 282 (9): 6398–404. doi: 10.1074/jbc.M610543200 . PMID 17194704.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169877 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11231637-3] Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med. 7 (3): 361–4. doi:10.1038/85515. PMID 11231637. S2CID 11499070.

[pmid12066189-4] Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature. 417 (6890): 758–63. Bibcode:2002Natur.417..758K. doi:10.1038/nature00803. PMID 12066189. S2CID 4362675.

[entrez-5] "Entrez Gene: ERAF erythroid associated factor".

[1]

[2]

[3]

[4]

[5]

ERAF

Related Research Articles

References

Further reading