ERLEC1

ERLEC1
Identifiers
Aliases	ERLEC1 , C2orf30, CIM, CL24936, CL25084, HEL117, XTP3-B, XTP3TPB, endoplasmic reticulum lectin 1
External IDs	OMIM: 611229; MGI: 1914003; HomoloGene: 9247; GeneCards: ERLEC1; OMA:ERLEC1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p16.2 Start 53,787,009 bp [1] End 53,833,038 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A4 Start 30,930,774 bp [2] End 30,954,335 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell endothelial cell mucosa of ileum cardiac muscle tissue of right atrium tibia tibialis anterior muscle pancreatic ductal cell decidua corpus epididymis middle temporal gyrus Top expressed in seminal vesicula Rostral migratory stream Epithelium of choroid plexus fossa parotid gland stroma of bone marrow islet of Langerhans supraoptic nucleus retinal pigment epithelium calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function unfolded protein binding protein binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum quality control compartment endoplasmic reticulum Biological process ERAD pathway negative regulation of retrograde protein transport, ER to cytosol transmembrane transport ubiquitin-dependent ERAD pathway retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27248 66753 Ensembl ENSG00000068912 ENSMUSG00000020311 UniProt Q96DZ1 Q8VEH8 RefSeq (mRNA) NM_001127397 NM_001127398 NM_015701 NM_025745 RefSeq (protein) NP_001120869 NP_001120870 NP_056516 NP_080021 Location (UCSC) Chr 2: 53.79 – 53.83 Mb Chr 11: 30.93 – 30.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endoplasmic reticulum lectin 1 is a protein that in humans is encoded by the ERLEC1 gene. ^{[5] [6] [7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000068912 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020311 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
6. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
7. Cruciat CM, Hassler C, Niehrs C (2006). "The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition". J. Biol. Chem. 281 (18): 12986–93. doi: 10.1074/jbc.M511872200 . PMID   16531414.
8. Christianson JC, Shaler TA, Tyler RE, Kopito RR (2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nat. Cell Biol. 10 (3): 272–82. doi:10.1038/ncb1689. PMC   2757077 . PMID   18264092.
9. "Entrez Gene: C2orf30 chromosome 2 open reading frame 30".

Further reading

• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.