ESAM (gene)

ESAM
Identifiers
Aliases	ESAM , W117m, endothelial cell adhesion molecule
External IDs	OMIM: 614281; MGI: 1916774; HomoloGene: 12316; GeneCards: ESAM; OMA:ESAM - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	124,762,290 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	37,449,615 bp
RNA expression pattern
	Top expressed in
	right lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; upper lobe of left lung; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; apex of heart; ; left coronary artery; ; subcutaneous adipose tissue;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; interventricular septum; ; decidua; ; digastric muscle; ; gastrula; ; cardiac muscles; ; myocardium of ventricle; ; right ventricle;
	More reference expression data
	More reference expression data
Orthologs
	90952
	69524
	ENSG00000149564
	ENSMUSG00000001946
	Q96AP7
	Q925F2
	NM_138961
	NM_027102
	NP_620411
	NP_081378
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 20, 2024

Endothelial cell-selective adhesion molecule is a protein that in humans is encoded by the ESAM gene.^[5]^[6]^[7] A mutation in the ESAM gene is known to cause fetal intracranial hemorrhaging.^[8]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149564 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001946 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirata Ki, Ishida T, Penta K, Rezaee M, Yang E, Wohlgemuth J, Quertermous T (May 2001). "Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells". J Biol Chem. 276 (19): 16223–16231. doi: 10.1074/jbc.M100630200 . PMID 11279107.
↑ Sim DL, Yeo WM, Chow VT (Mar 2002). "The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner". Int J Biochem Cell Biol. 34 (5): 487–504. doi:10.1016/S1357-2725(01)00156-X. PMID 11906820.
↑ "Entrez Gene: ESAM endothelial cell adhesion molecule".
↑ "Entry - #620371 - NEURODEVELOPMENTAL DISORDER WITH INTRACRANIAL HEMORRHAGE, SEIZURES, AND SPASTICITY; NEDIHSS - OMIM". omim.org. Retrieved 2024-11-19.

Nasdala I, Wolburg-Buchholz K, Wolburg H, et al. (2002). "A transmembrane tight junction protein selectively expressed on endothelial cells and platelets". J. Biol. Chem. 277 (18): 16294–16303. doi: 10.1074/jbc.M111999200 . PMID 11847224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149564 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001946 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279107-5] Hirata Ki, Ishida T, Penta K, Rezaee M, Yang E, Wohlgemuth J, Quertermous T (May 2001). "Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells". J Biol Chem. 276 (19): 16223–16231. doi: 10.1074/jbc.M100630200 . PMID 11279107.

[pmid11906820-6] Sim DL, Yeo WM, Chow VT (Mar 2002). "The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner". Int J Biochem Cell Biol. 34 (5): 487–504. doi:10.1016/S1357-2725(01)00156-X. PMID 11906820.

[entrez-7] "Entrez Gene: ESAM endothelial cell adhesion molecule".

[8] "Entry - #620371 - NEURODEVELOPMENTAL DISORDER WITH INTRACRANIAL HEMORRHAGE, SEIZURES, AND SPASTICITY; NEDIHSS - OMIM". omim.org. Retrieved 2024-11-19.

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ESAM (gene)

Related Research Articles

References

Further reading