EVI5

EVI5
Identifiers
Aliases	EVI5 , NB4S, EVI-5, ecotropic viral integration site 5
External IDs	OMIM: 602942 MGI: 104736 HomoloGene: 121902 GeneCards: EVI5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	92,792,404 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,022,973 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; seminal vesicula; ; parietal pleura; ; corpus callosum; ; visceral pleura; ; internal globus pallidus; ; germinal epithelium; ; placenta; ; bronchial epithelial cell;
	Top expressed in
	sciatic nerve; ; secondary oocyte; ; saccule; ; facial motor nucleus; ; left lobe of liver; ; cumulus cell; ; utricle; ; otic placode; ; optic nerve; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; GTPase activator activity ;
Cellular component	cytoplasm ; cytosol ; spindle ; cytoskeleton ; nucleus ; microtubule organizing center ; endomembrane system ; Golgi apparatus ; intracellular membrane-bounded organelle ;
Biological process	cell division ; multicellular organism development ; regulation of cilium assembly ; regulation of GTPase activity ; cell cycle ; cell population proliferation ; retrograde transport, endosome to Golgi ; regulation of vesicle fusion ; intracellular protein transport ; activation of GTPase activity ; positive regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	7813
	14020
	ENSG00000067208
	ENSMUSG00000011831
	O60447
	P97366
NM_001308248 ; NM_005665 ; NM_001350197 ; NM_001350198 ; NM_001377210 ;
	NM_001377211 ; NM_001377212 ; NM_001377213
	NM_007964 ; NM_001378824 ; NM_001378825
NP_001295177 ; NP_005656 ; NP_001337126 ; NP_001337127 ; NP_001364139 ;
	NP_001364140 ; NP_001364141 ; NP_001364142
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Ecotropic viral integration site 5 protein homolog is a protein that in humans is encoded by the EVI5 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000067208 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011831 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Roberts T, Chernova O, Cowell JK (Jul 1998). "NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma". Human Molecular Genetics. 7 (7): 1169–78. doi: 10.1093/hmg/7.7.1169 . PMID 9618176.
↑ "Entrez Gene: EVI5 ecotropic viral integration site 5".

Dabbeekeh JT, Faitar SL, Dufresne CP, Cowell JK (Apr 2007). "The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11". Oncogene. 26 (19): 2804–8. doi: 10.1038/sj.onc.1210081 . PMID 17099728.
Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG (Jan 2007). "Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1236–41. Bibcode:2007PNAS..104.1236W. doi: 10.1073/pnas.0610500104 . PMC 1773056 . PMID 17229837.
Faitar SL, Sossey-Alaoui K, Ranalli TA, Cowell JK (Jul 2006). "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis". Experimental Cell Research. 312 (12): 2325–35. doi:10.1016/j.yexcr.2006.03.032. PMID 16764853.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (Jan 2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi: 10.1016/j.cell.2005.10.038 . PMID 16439210. S2CID 15578836.
Faitar SL, Dabbeekeh JT, Ranalli TA, Cowell JK (Nov 2005). "EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin". Genomics. 86 (5): 594–605. doi:10.1016/j.ygeno.2005.06.002. PMID 16033705.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000067208 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011831 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9618176-5] Roberts T, Chernova O, Cowell JK (Jul 1998). "NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma". Human Molecular Genetics. 7 (7): 1169–78. doi: 10.1093/hmg/7.7.1169 . PMID 9618176.

[entrez-6] "Entrez Gene: EVI5 ecotropic viral integration site 5".

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EVI5

Related Research Articles

References

Further reading