EXOC6

EXOC6
Identifiers
Aliases	EXOC6 , EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p, exocyst complex component 6
External IDs	OMIM: 609672 MGI: 1351611 HomoloGene: 41305 GeneCards: EXOC6
Gene location (Human)
Chr.	Chromosome 10 (human)
End	93,059,493 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	37,672,507 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; pancreatic epithelial cell; ; vastus lateralis muscle; ; middle temporal gyrus; ; tibialis anterior muscle; ; islet of Langerhans; ; placenta; ; visceral pleura; ; endothelial cell; ; gastrocnemius muscle;
	Top expressed in
	soleus muscle; ; extraocular muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; intercostal muscle; ; triceps brachii muscle; ; thoracic diaphragm; ; Region I of hippocampus proper; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytosol ; plasma membrane ; exocyst ; cytoplasm ; growth cone ; cell projection ; perinuclear region of cytoplasm ; Flemming body ; membrane ;
Biological process	protein transport ; vesicle docking involved in exocytosis ; exocytosis ; Golgi to plasma membrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	54536
	107371
	ENSG00000138190
	ENSMUSG00000053799
	Q8TAG9
	Q8R313
	NM_001013848 ; NM_019053 ; NM_001319194 ; NM_001319195 ; NM_001319200 Contents Function ; References ; Further reading ;
	NM_175353
	NP_001013870 ; NP_001306123 ; NP_001306124 ; NP_001306129 ; NP_061926
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.^[5]

Function

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

Related Research Articles

Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with neurological disorders including epilepsy, intellectual disability, and movement disorders.

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

Rab proteins geranylgeranyltransferase component A 2 is an enzyme that in humans is encoded by the CHML gene.

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.

Exocyst complex component 8 is a protein that in humans is encoded by the EXOC8 gene.

Rab11 family-interacting protein 4 is a protein that in humans is encoded by the RAB11FIP4 gene.

Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene. CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation.

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Exocyst complex component 3-like is a protein that in humans is encoded by the EXOC3L gene.

Exocyst complex component 6B is a protein that in humans is encoded by the EXOC6B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138190 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053799 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Exocyst complex component 6".

Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T (October 2004). "Sec15 is an effector for the Rab11 GTPase in mammalian cells". The Journal of Biological Chemistry. 279 (41): 43027–34. doi: 10.1074/jbc.M402264200 . PMID 15292201.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". American Journal of Human Genetics. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225 . PMID 16385451.
France YE, Boyd C, Coleman J, Novick PJ (March 2006). "The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit". Journal of Cell Science. 119 (Pt 5): 876–88. doi: 10.1242/jcs.02849 . PMID 16478783.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E (October 2010). "Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst". Nature. 467 (7317): 854–8. Bibcode:2010Natur.467..854G. doi:10.1038/nature09446. PMC 5831355 . PMID 20944747.
Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB (October 2010). "An integrative method for scoring candidate genes from association studies: application to warfarin dosing". BMC Bioinformatics. 11 Suppl 9: S9. doi:10.1186/1471-2105-11-S9-S9. PMC 2967750 . PMID 21044367.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138190 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053799 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Exocyst complex component 6".

[1]

[2]

[3]

[4]

[5]

EXOC6

Contents

Function

Related Research Articles

References

Further reading