EXOC8

EXOC8
Identifiers
Aliases	EXOC8 , EXO84, Exo84p, SEC84, exocyst complex component 8, NEDMISB
External IDs	OMIM: 615283 MGI: 2142527 HomoloGene: 44545 GeneCards: EXOC8
Gene location (Human)
Chr.	Chromosome 1 (human)
End	231,337,852 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	125,624,444 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; deltoid muscle; ; endothelial cell; ; germinal epithelium; ; parietal pleura; ; Brodmann area 23; ; visceral pleura; ; amniotic fluid; ; tibialis anterior muscle; ; palpebral conjunctiva;
	Top expressed in
	spermatocyte; ; pineal gland; ; parotid gland; ; epithelium of stomach; ; lacrimal gland; ; brown adipose tissue; ; conjunctival fornix; ; seminal vesicula; ; ciliary body; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	late endosome ; cell projection ; membrane ; growth cone ; plasma membrane ; exocyst ; cytoplasm ; cytosol ; perinuclear region of cytoplasm ; cell leading edge ;
Biological process	extracellular matrix disassembly ; endosome organization ; exocyst localization ; exocyst assembly ; protein transport ; regulation of macroautophagy ; exocytosis ; transport ; Golgi to plasma membrane transport ; protein localization ;
	Sources:Amigo / QuickGO
Orthologs
	149371
	102058
	ENSG00000116903
	ENSMUSG00000074030
	Q8IYI6
	Q6PGF7
	NM_175876
	NM_198103
	NP_787072
	NP_932771
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 30, 2024

Exocyst complex component 8 is a protein that in humans is encoded by the EXOC8 gene.^[5]^[6]

Interactions

EXOC8 has been shown to interact with RALB.^[7]

Related Research Articles

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.

Vesicle-associated membrane protein 7 (VAMP-7), is a protein that in humans is encoded by the VAMP7 gene also known as the or SYBL1 gene.

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.

Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene.

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene.

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116903 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074030 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
↑ "Entrez Gene: EXOC8 exocyst complex component 8".
↑ Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID 14525976.

Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. Bibcode:1997PNAS...9414438K. doi: 10.1073/pnas.94.26.14438 . PMC 25013 . PMID 9405631.
Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi: 10.1016/S0896-6273(00)80493-6 . PMID 9655500. S2CID 10915358.
Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–7. doi: 10.1074/jbc.C100320200 . PMID 11406615.
Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID 12687004. S2CID 4395760.
Wang S, Hsu SC (2004). "Immunological characterization of exocyst complex subunits in cell differentiation". Hybrid. Hybridomics. 22 (3): 159–64. doi:10.1089/153685903322286575. PMID 12954101.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID 14525976.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116903 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074030 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

[entrez-6] "Entrez Gene: EXOC8 exocyst complex component 8".

[pmid14525976-7] Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID 14525976.

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EXOC8

Contents

Interactions

Related Research Articles

References

Further reading