EXOC8

EXOC8
Identifiers
Aliases	EXOC8 , EXO84, Exo84p, SEC84, exocyst complex component 8, NEDMISB
External IDs	OMIM: 615283; MGI: 2142527; HomoloGene: 44545; GeneCards: EXOC8; OMA:EXOC8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.2 Start 231,332,753 bp [1] End 231,337,852 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E2 Start 125,619,847 bp [2] End 125,624,444 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell deltoid muscle endothelial cell germinal epithelium parietal pleura skin of thigh Brodmann area 23 visceral pleura amniotic fluid tibialis anterior muscle Top expressed in spermatocyte pineal gland parotid gland epithelium of stomach lacrimal gland brown adipose tissue conjunctival fornix stroma of bone marrow seminal vesicula ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component late endosome cell projection membrane growth cone plasma membrane exocyst cytoplasm cytosol perinuclear region of cytoplasm cell leading edge Biological process extracellular matrix disassembly endosome organization exocyst localization exocyst assembly protein transport regulation of macroautophagy exocytosis transport Golgi to plasma membrane transport protein localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149371 102058 Ensembl ENSG00000116903 ENSMUSG00000074030 UniProt Q8IYI6 Q6PGF7 RefSeq (mRNA) NM_175876 NM_198103 RefSeq (protein) NP_787072 NP_932771 Location (UCSC) Chr 1: 231.33 – 231.34 Mb Chr 8: 125.62 – 125.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exocyst complex component 8 is a protein that in humans is encoded by the EXOC8 gene. ^{[5] [6]}

Interactions

EXOC8 has been shown to interact with RALB. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116903 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074030 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: EXOC8 exocyst complex component 8".
7. Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID   14525976.

Further reading

• Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. Bibcode:1997PNAS...9414438K. doi: 10.1073/pnas.94.26.14438 . PMC   25013 . PMID   9405631.
• Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi: 10.1016/S0896-6273(00)80493-6 . PMID   9655500. S2CID   10915358.
• Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–7. doi: 10.1074/jbc.C100320200 . PMID   11406615.
• Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID   12687004. S2CID   4395760.
• Wang S, Hsu SC (2004). "Immunological characterization of exocyst complex subunits in cell differentiation". Hybrid. Hybridomics. 22 (3): 159–64. doi:10.1089/153685903322286575. PMID   12954101.
• Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID   14525976.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.