Expressive aphasia is a type of aphasia characterized by partial loss of the ability to produce language, although comprehension generally remains intact. A person with expressive aphasia will exhibit effortful speech. Speech generally includes important content words but leaves out function words that have more grammatical significance than physical meaning, such as prepositions and articles. This is known as "telegraphic speech". The person's intended message may still be understood, but their sentence will not be grammatically correct. In very severe forms of expressive aphasia, a person may only speak using single word utterances. Typically, comprehension is mildly to moderately impaired in expressive aphasia due to difficulty understanding complex grammar.
Kinesiology is the scientific study of human body movement. Kinesiology addresses physiological, anatomical, biomechanical, pathological, neuropsychological principles and mechanisms of movement. Applications of kinesiology to human health include biomechanics and orthopedics; strength and conditioning; sport psychology; motor control; skill acquisition and motor learning; methods of rehabilitation, such as physical and occupational therapy; and sport and exercise physiology. Studies of human and animal motion include measures from motion tracking systems, electrophysiology of muscle and brain activity, various methods for monitoring physiological function, and other behavioral and cognitive research techniques.
Ingrid Elizabeth Newkirk is a British-American animal activist, author and the president of People for the Ethical Treatment of Animals (PETA), the world's largest animal rights organization.
Alexander Fernando Pacheco is an American animal rights activist. He is the founder of 600 Million Dogs, co-founder and former chairman of People for the Ethical Treatment of Animals (PETA) and a member of the advisory board of the Sea Shepherd Conservation Society.
Cortical maps are collections (areas) of minicolumns in the brain cortex that have been identified as performing a specific information processing function.
The primary goals of stroke management are to reduce brain injury and promote maximum patient recovery. Rapid detection and appropriate emergency medical care are essential for optimizing health outcomes. When available, patients are admitted to an acute stroke unit for treatment. These units specialize in providing medical and surgical care aimed at stabilizing the patient's medical status. Standardized assessments are also performed to aid in the development of an appropriate care plan. Current research suggests that stroke units may be effective in reducing in-hospital fatality rates and the length of hospital stays.
Neuroplasticity, also known as neural plasticity or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization. It is when the brain is rewired to function in some way that differs from how it previously functioned. These changes range from individual neuron pathways making new connections, to systematic adjustments like cortical remapping or neural oscillation. Other forms of neuroplasticity include homologous area adaptation, cross modal reassignment, map expansion, and compensatory masquerade. Examples of neuroplasticity include circuit and network changes that result from learning a new ability, information acquisition, environmental influences, pregnancy, caloric intake, practice/training, and psychological stress.
The Silver Spring monkeys were 17 wild-born macaque monkeys from the Philippines who were kept in the Institute for Behavioral Research in Silver Spring, Maryland. From 1981 until 1991, they became what one writer called the most famous lab animals in history, as a result of a battle between animal researchers, animal advocates, politicians, and the courts over whether to use them in research or release them to a sanctuary. Within the scientific community, the monkeys became known for their use in experiments into neuroplasticity—the ability of the adult primate brain to reorganize itself.
Neal Elgar Miller was an American experimental psychologist. Described as an energetic man with a variety of interests, including physics, biology and writing, Miller entered the field of psychology to pursue these. With a background training in the sciences, he was inspired by professors and leading psychologists at the time to work on various areas in behavioral psychology and physiological psychology, specifically, relating visceral responses to behavior.
Michael Matthias Merzenich is an American neuroscientist and professor emeritus at the University of California, San Francisco. He took the sensory cortex maps developed by his predecessors and refined them using dense micro-electrode mapping techniques. Using this, he definitively showed there to be multiple somatotopic maps of the body in the postcentral sulcus, and multiple tonotopic maps of the acoustic inputs in the superior temporal plane.
The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science is a book on neuroplasticity by psychiatrist and psychoanalyst Norman Doidge.
Constraint-induced movement therapy is a form of rehabilitation therapy that improves upper extremity function in stroke and other central nervous system damage patients by increasing the use of their affected upper limb. Due to its high duration of treatment, the therapy has been found to frequently be infeasible when attempts have been made to apply it to clinical situations, and both patients and treating clinicians have reported poor compliance and concerns with patient safety. In the United States, the high duration of the therapy has also made the therapy not able to get reimbursed in most clinical environments.
Learned non-use of a limb is a learning phenomenon whereby movement is suppressed initially due to adverse reactions and failure of any activity attempted with the affected limb, which then results in the suppression of behavior. Continuation of this response results in persisting tendency and consequently, the individual never learns that the limb may have become potentially useful. By constraining the less-affected limb there is a change in motivation, which overcomes the learned nonuse of the more-affected limb.
Activity-dependent plasticity is a form of functional and structural neuroplasticity that arises from the use of cognitive functions and personal experience; hence, it is the biological basis for learning and the formation of new memories. Activity-dependent plasticity is a form of neuroplasticity that arises from intrinsic or endogenous activity, as opposed to forms of neuroplasticity that arise from extrinsic or exogenous factors, such as electrical brain stimulation- or drug-induced neuroplasticity. The brain's ability to remodel itself forms the basis of the brain's capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is associated with neural plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity occurs as a result of changes in gene expression which are triggered by signaling cascades that are activated by various signaling molecules during increased neuronal activity.
Norman Doidge,, is a psychiatrist, psychoanalyst, and author of The Brain that Changes Itself and The Brain's Way of Healing.
Sensory stimulation therapy (SST) is an experimental therapy that aims to use neural plasticity mechanisms to aid in the recovery of somatosensory function after stroke or cognitive ageing. Stroke and cognitive ageing are well known sources of cognitive loss, the former by neuronal death, the latter by weakening of neural connections. SST stimulates a specific sense at a specific frequency. Research suggests that this technique may reverse cognitive ageing by up to 30 years, and may selectively improve or impair two point discrimination thresholds.
Restorative neurology is a branch of neurology dedicated to improving functions of the impaired nervous system through selective structural or functional modification of abnormal neurocontrol according to underlying mechanisms and clinically unrecognized residual functions. When impaired, the body naturally reconstructs new neurological pathways and redirects activity. The field of restorative neurology works to accentuate these new pathways and primarily focuses on the theory of the plasticity of an impaired nervous system. Its main goal is to take a broken down and disordered nervous system and return it to a state of normal function. Certain treatment strategies are used to augment instead of fully replace any performance of surviving and also improving the potential of motor neuron functions. This rehabilitation of motor neurons allows patients a therapeutic approach to recovery opposed to physical structural reconstruction. It is applied in a wide range of disorders of the nervous system, including upper motor neuron dysfunctions like spinal cord injury, cerebral palsy, multiple sclerosis and acquired brain injury including stroke, and neuromuscular diseases as well as for control of pain and spasticity. Instead of applying a reconstructive neurobiological approach, i.e. structural modifications, restorative neurology relies on improving residual function. While subspecialties like neurosurgery and pharmacology exist and are useful in diagnosing and treating conditions of the nervous system, restorative neurology takes a pathophysiological approach. Instead of heavily relying on neurochemistry or perhaps an anatomical discipline, restorative neurology encompasses many fields and blends them together.
Cortical remapping, also referred to as cortical reorganization, is the process by which an existing cortical map is affected by a stimulus resulting in the creating of a 'new' cortical map. Every part of the body is connected to a corresponding area in the brain which creates a cortical map. When something happens to disrupt the cortical maps such as an amputation or a change in neuronal characteristics, the map is no longer relevant. The part of the brain that is in charge of the amputated limb or neuronal change will be dominated by adjacent cortical regions that are still receiving input, thus creating a remapped area. Remapping can occur in the sensory or motor system. The mechanism for each system may be quite different. Cortical remapping in the somatosensory system happens when there has been a decrease in sensory input to the brain due to deafferentation or amputation, as well as a sensory input increase to an area of the brain. Motor system remapping receives more limited feedback that can be difficult to interpret.
Peter G. Levine was an American medical researcher, science educator, and authority on stroke recovery. He published articles on brain plasticity as it relates to stroke, with emphasis on modified constraint induced therapy, cortical reorganization, telerehabilitation, electrical stimulation, electromyography-triggered stimulation, mental practice, cortical plasticity, acquired brain injury, spasticity, sensation recovery, evidence-based practice, outcome measures, and others. His 2013 book Stronger After Stroke is regarded as an authoritative guide for patients and therapists dealing with stroke. The book has received numerous positive reviews, and has been translated into Indonesian, Japanese, and Korean. His seminars throughout the United States were described by one reviewer as "funny, entertaining, engaging, dynamic, well organized, passionate and lighthearted." Levine was a trainer of stroke-specific outcome measures for The Ohio State University; B.R.A.I.N. Lab. He was a researcher and co-director at the Neuromotor Recovery and Rehabilitation Laboratory at the University of Cincinnati College of Medicine. Before that, he was a researcher at the Human Performance & Motion Analysis Laboratory, which is the research arm of the Kessler Institute for Rehabilitation.
Stephen J. Page is an American biomedical researcher, author, clinician, and science educator who is known for his research on motor recovery and care after stroke. Page has developed stroke interventions such as modified constraint-induced movement therapy, and applications of mental practice in neurorehabilitation, including the first application of mental practice to stroke survivors to increase neuroplasticity. Page has also authored works about topics such as electrical stimulation, myoelectrics, outcome measurement, and neuromodulation. He has held professorial positions at academic institutions such as The Ohio State University Medical Center and The University of Cincinnati College of Medicine.
