EPC2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | EPC2 , EPC-LIKE, enhancer of polycomb homolog 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611000 MGI: 1278321 HomoloGene: 32274 GeneCards: EPC2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Enhancer of polycomb homolog 2 (Drosophila) is a protein that in humans is encoded by the EPC2 gene. [5]
Polycomb-group proteins are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place. Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. They derive their name from the fact that the first sign of a decrease in PcG function is often a homeotic transformation of posterior legs towards anterior legs, which have a characteristic comb-like set of bristles.
Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.
Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.
Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene. BMI1 is a polycomb ring finger oncogene.
Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.
Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.
E1A-binding protein p400 is a protein that in humans is encoded by the EP400 gene.
Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene.
K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.
Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.
Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.
Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.
Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.
JADE1 is a protein that in humans is encoded by the JADE1 gene.
Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.
ASH1L is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1.
Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene.
Trithorax-group proteins (TrxG) are a heterogeneous collection of proteins whose main action is to maintain gene expression. They can be categorized into three general classes based on molecular function:
Malignant Brain Tumor domain containing 1 is a protein that in humans is encoded by the MBTD1 gene. The gene is also known as SA49P01.