Enmetazobactam

Last updated

Enmetazobactam
Enmetazobactam.svg
Legal status
Legal status
Identifiers
  • (2S,3S,5R)-3-methyl-3-[(3-methyltriazol-3-ium-1-yl)methyl]-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C11H14F2N4O5S
Molar mass 352.31 g·mol−1
3D model (JSmol)
  • C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=C[N+](=N3)C
  • InChI=1S/C11H14N4O5S/c1-11(6-14-4-3-13(2)12-14)9(10(17)18)15-7(16)5-8(15)21(11,19)20/h3-4,8-9H,5-6H2,1-2H3/t8-,9+,11+/m1/s1
  • Key:HFZITXBUTWITPT-YWVKMMECSA-N

Enmetazobactam (AAI-101) is an antibiotic adjuvant drug which acts as a beta-lactamase inhibitor, preventing the breakdown of other antibiotic drugs. [1] Enmetazobactam was invented by a team of scientists at Orchid Pharma in India and then out-licensed to Allecra Therapeutics for further development. [2] In the United States and European Union, enmetazobactam is approved for use in the combination cefepime/enmetazobactam (Exblifep). [3] [4]

References

  1. Lanier C, Melton T, Covert K (September 2024). "Cefepime-Enmetazobactam: A Drug Review of a Novel Beta-Lactam/Beta-Lactamase Inhibitor". The Annals of Pharmacotherapy. 59 (6): 570–576. doi:10.1177/10600280241279904. PMID   39329253.
  2. US patent No.7687488B2 Novel 2-substituted methyl penam derivatives, https://worldwide.espacenet.com/patent/search/family/038949982/publication/US7687488B2?q=pn%3DUS7687488 Archived 5 April 2024 at the Wayback Machine
  3. New Drug Therapy Approvals 2024 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2025. Archived from the original on 21 January 2025. Retrieved 21 January 2025.
  4. "Exblifep EPAR". European Medicines Agency (EMA). 25 January 2024. Archived from the original on 4 February 2024. Retrieved 3 February 2024. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.