Enrica Bordignon

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Enrica Bordignon
Born (1975-04-05) 5 April 1975 (age 50)
NationalityItalian
Alma mater University of Padua
Scientific career
Institutions Ruhr University Bochum
Free University of Berlin
Osnabrück University
ETH Zurich
University of Geneva
Thesis  (2000)

Enrica Bordignon (born 5 April 1975) is an Italian chemist and Chair of Electron Spin Resonance at the University of Geneva. Her research involves the development of electron paramagnetic resonance to study membrane potentials.

Contents

Early life and education

Bordignon was an undergraduate student and doctoral researcher at the University of Padua. Her doctoral research investigated the photo-physical properties of reaction centres in antenna complexes. [1] During her doctorate, she worked at Berlin's Max Volmer Laboratory. She completed her undergraduate studies summa cum laude in 1999. She was a postdoctoral researcher at the Osnabrück University and ETH Zurich. [2] At Osnabrück Bordignon studied bacterial photoaxis membrane protein complexes (including Neuropeptide S receptors) and ABC-transporters (including Escherichia coli) using spin labelling. [1] At Zurich Bordignon continued to apply spin labelling to investigate the ATP-binding cassette transporters, including BtuCD-F vitamin B12 importer. [1]

Research and career

In 2013 Bordignon was made a professor of biophysics at the Free University of Berlin. Her research uses site-directed spin labelling EPR to understand the dynamics and conformational changes of membrane proteins. Membrane proteins are the targets of many pharmaceuticals. Transporter membranes move substances in and out of the cellular environment. [3] Bordignon has shown that EPR can be used to study membrane potentials in situ , i.e. in cells. She has particularly developed double electron–electron resonance (DEER), which can be used to monitor one system of spins while exciting another set of spins at a second microwave frequency. [4] She was the first to use spin-labelled nanobodies to report cellular membrane potentials. [5] She moved to the Ruhr University Bochum in 2016. She was appointed Professor of Chemistry at the University of Geneva in 2021, and made Vice Dean for Science in 2023. [6]

Awards and honours

Select publications

Personal life

Bordignon has one child. [2]

References

  1. 1 2 3 "IRTG summer school & 6th Westerberger Herbsttagung" (PDF).
  2. 1 2 "Enrica Bordignon - Bordignon Research Group - UNIGE". www.unige.ch. 18 November 2019. Retrieved 19 November 2023.
  3. ↑ "Innovative Method To Observe Cell Transport Developed". Cell Science from Technology Networks. Retrieved 19 November 2023.
  4. ↑ Galazzo, Laura; Teucher, Markus; Bordignon, Enrica (2022), "Orthogonal spin labeling and pulsed dipolar spectroscopy for protein studies" , Methods in Enzymology, vol. 666, Elsevier, pp. 79–119, doi:10.1016/bs.mie.2022.02.004, ISBN   978-0-323-99974-8 , retrieved 19 November 2023
  5. ↑ Galazzo, Laura; Meier, Gianmarco; Timachi, M. Hadi; Hutter, Cedric A. J.; Seeger, Markus A.; Bordignon, Enrica (4 February 2020). "Spin-labeled nanobodies as protein conformational reporters for electron paramagnetic resonance in cellular membranes". Proceedings of the National Academy of Sciences. 117 (5): 2441–2448. doi:10.1073/pnas.1913737117. ISSN   0027-8424. PMC   7007536 . PMID   31964841.
  6. ↑ "Dean's Office - Faculté des sciences". www.unige.ch. 10 December 2007. Retrieved 19 November 2023.
  7. ↑ "Profile". www.humboldt-foundation.de. Retrieved 19 November 2023.
  8. ↑ "Enrica Bordignon | IEPRS". ieprs.org. 27 June 2019. Retrieved 19 November 2023.
  9. ↑ "John Weil Young Investigator Awards | IEPRS". ieprs.org. Retrieved 19 November 2023.
  10. ↑ "ampere-society". www.ampere-society.org. Retrieved 19 November 2023.
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