| EPSTI1 | |||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||
| Aliases | EPSTI1 , BRESI1, epithelial stromal interaction 1 (breast), epithelial stromal interaction 1 | ||||||||||||||||||||||||
| External IDs | OMIM: 607441 MGI: 1915168 HomoloGene: 12630 GeneCards: EPSTI1 | ||||||||||||||||||||||||
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| Orthologs | |||||||||||||||||||||||||
| Species | Human | Mouse | |||||||||||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||||||||||
| RefSeq (protein) | |||||||||||||||||||||||||
| Location (UCSC) | Chr 13: 42.89 – 42.99 Mb | Chr 14: 77.9 – 78 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||
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Epithelial stromal interaction 1 is a protein that in humans is encoded by the EPSTI1 gene. [5]
The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE).
Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.
Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.
TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.
SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.
Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.
Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.
Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.
ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.
Juxtaposed with another zinc finger protein 1 (JAZF1) also known as TAK1-interacting protein 27 (TIP27) or zinc finger protein 802 (ZNF802) is a protein that in humans is encoded by the JAZF1 gene. Variants are associated with an increased risk of prostate cancer, an increased risk of type 2 diabetes, and an increased height.
Fyn-related kinase is an enzyme that in humans is encoded by the FRK gene.
Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.
Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.
Ectodysplasin-A receptor-associated adapter protein is a protein that in humans is encoded by the EDARADD gene.
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.
Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.
Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene.
Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.
 | This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
