Erucamide

Erucamide

Names
IUPAC name (Z)-Docos-13-enamide
Other names Erucylamide Erucic acid amide Erucic amide cis-13-Docosenamide
Identifiers
CAS Number	112-84-5
3D model (JSmol)	Interactive image
ECHA InfoCard	100.003.645
PubChem CID	5365371
CompTox Dashboard (EPA)	DTXSID4026929
InChI InChI=1S/C22H43NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h9-10H,2-8,11-21H2,1H3,(H2,23,24)/b10-9- Key: UAUDZVJPLUQNMU-KTKRTIGZSA-N
SMILES CCCCCCCC/C=C\CCCCCCCCCCCC(=O)N
Properties
Chemical formula	C22H43NO
Molar mass	337.592 g·mol−1
Appearance	White solid [1]
Melting point	83.5–84 °C (182.3–183.2 °F; 356.6–357.1 K) [1]
Solubility in water	Insoluble [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Erucamide is a fatty acid amide resulting from the formal condensation of erucic acid with ammonia. It has a role as a metabolite in humans and other animals and in plants. ^[2] In the plastic manufacturing industry, it is commonly used as a slip additive. ^{[2] [3]}

Uses

Erucamide is used as a slip promoter, antiblock agent, and lubricant in plastics. ^[4] It serves as a viscosity controlling and opacifying agent in cosmetics. ^[5] In industry, it functions as a processing aid, lubricating agent, anti-adhesive agent, and corrosion inhibitor. In the United States, it is authorized as an indirect food additive in adhesives under 21 CFR 175.105. ^[6]

Research

Erucamide has been reported to ameliorate depression and anxiety-like behaviors in mouse models. ^[7]

References

1. Record in the GESTIS Substance Database of the Institute for Occupational Safety and Health
2. CID 5365371 from PubChem
3. "CHEBI:142245 - erucamide". ChEBI .
4. "Erucamide". Lepuz.
5. "Erucamide: An In-Depth Look at Its Role in Cosmetics". Deascal. October 15, 2024.
6. 21 CFR 175.105
7. Miao-Miao Li, Zheng-er Jiang, Ling-Yun Song, Zhe-Shan Quan, Hai-Ling Yu (2017). "Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus–pituitary–adrenal axis in mice". Neuroscience Letters. 640: 6–12. doi:10.1016/j.neulet.2016.12.072.