Ets variant 2

ETV2
Identifiers
Aliases	ETV2 , ER71, ETSRP71, Ets variant 2, ETS variant transcription factor 2
External IDs	OMIM: 609358 MGI: 99253 HomoloGene: 7308 GeneCards: ETV2
Gene location (Human)
Chr.	Chromosome 19 (human) [1]
End	35,644,871 bp [1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse) [2]
End	30,635,852 bp [2]
Gene ontology
Molecular function	• DNA binding ; • sequence-specific DNA binding ; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	• cell nucleus ;
Biological process	• Notch signaling pathway ; • cell differentiation ; • positive regulation of endothelial cell differentiation ; • regulation of transcription, DNA-templated ; • blood vessel morphogenesis ; • placenta development ; • regulation of transcription from RNA polymerase II promoter ; • mesoderm formation ; • in utero embryonic development ; • Wnt signaling pathway ; • transcription from RNA polymerase II promoter ; • positive regulation of mesoderm development ; • positive regulation of gene expression ; • BMP signaling pathway involved in mesodermal cell fate specification ; • erythrocyte differentiation ; • blastocyst development ; • positive regulation of transcription from RNA polymerase II promoter ; • haematopoiesis ;
	Sources:Amigo / QuickGO
Orthologs
	2116
	14008
	ENSG00000105672
	ENSMUSG00000006311
	O00321
	P41163
	NM_001300974 ; NM_001304549 ; NM_014209
	NM_007959
	NP_001287903 ; NP_001291478 ; NP_055024
	NP_031985
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 18, 2020

Ets variant 2 is a protein that in humans is encoded by the ETV2 gene.^[5] It is a transcription factor and also plays a role in vascular endothelial cell development.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105672 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006311 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ets variant 2".
↑ Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993 . PMID 26694034.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105672 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006311 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ets variant 2".

[6] Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993 . PMID 26694034.