Exocyst complex component 6b

EXOC6B
Identifiers
Aliases	EXOC6B , SEC15B, SEC15L2, exocyst complex component 6B, SEMDJL3
External IDs	OMIM: 607880 MGI: 1923164 HomoloGene: 44781 GeneCards: EXOC6B
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.2 Start 72,175,984 bp [1] End 72,826,041 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 C3 Start 84,595,469 bp [2] End 85,046,495 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon internal globus pallidus corpus callosum sural nerve external globus pallidus left ventricle skin of abdomen right ventricle inferior ganglion of vagus nerve superior vestibular nucleus Top expressed in olfactory epithelium superior frontal gyrus hippocampus proper molar neural tube subiculum cerebellar cortex dorsal tegmental nucleus supraoptic nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component exocyst membrane Biological process exocytosis vesicle docking involved in exocytosis protein transport Golgi to plasma membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23233 75914 Ensembl ENSG00000144036 ENSMUSG00000033769 UniProt Q9Y2D4 A6H5Z3 RefSeq (mRNA) NM_015189 NM_001321729 NM_001321730 NM_001321731 NM_001321733 NM_001321734 NM_177077 RefSeq (protein) NP_001308658 NP_001308659 NP_001308660 NP_001308662 NP_001308663 NP_056004 NP_796051 Location (UCSC) Chr 2: 72.18 – 72.83 Mb Chr 6: 84.6 – 85.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exocyst complex component 6B is a protein that in humans is encoded by the EXOC6B gene. ^[5]

Function

In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144036 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033769 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Exocyst complex component 6B".

Further reading

• Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (August 2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". The Journal of Biological Chemistry. 276 (32): 29792–7. doi: 10.1074/jbc.C100320200 . PMID   11406615.
• Feng S, Knödler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peränen J, Guo W (May 2012). "A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis". The Journal of Biological Chemistry. 287 (19): 15602–9. doi: 10.1074/jbc.M111.333245 . PMC   3346093 . PMID   22433857.
• Wen J, Lopes F, Soares G, Farrell SA, Nelson C, Qiao Y, Martell S, Badukke C, Bessa C, Ylstra B, Lewis S, Isoherranen N, Maciel P, Rajcan-Separovic E (July 2013). "Phenotypic and functional consequences of haploinsufficiency of genes from exocyst and retinoic acid pathway due to a recurrent microdeletion of 2p13.2". Orphanet Journal of Rare Diseases. 8: 100. doi: 10.1186/1750-1172-8-100 . PMC   3710273 . PMID   23837398.
• Borsani G, Piovani G, Zoppi N, Bertini V, Bini R, Notarangelo L, Barlati S (2008). "Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype". European Journal of Medical Genetics. 51 (4): 292–302. doi:10.1016/j.ejmg.2008.02.006. PMID   18424204.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.