FAM114A2

Last updated
FAM114A2
Identifiers
Aliases FAM114A2 , 133K02, C5orf3, family with sequence similarity 114 member A2
External IDs MGI: 1917629 HomoloGene: 10270 GeneCards: FAM114A2
Orthologs
SpeciesHumanMouse
Entrez

10827

67726

Ensembl

ENSG00000055147

ENSMUSG00000020523

UniProt

Q9NRY5

Q8VE88

RefSeq (mRNA)

NM_018691
NM_001317993
NM_001317994
NM_001317995

NM_001168667
NM_001168668
NM_026342

RefSeq (protein)

NP_001304922
NP_001304923
NP_001304924
NP_061161

NP_001162138
NP_001162139
NP_080618

Location (UCSC) Chr 5: 153.99 – 154.04 Mb Chr 11: 57.48 – 57.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

Contents

SpeciesAccession #Identity
macaca mulatta XM_00110246778.1%
Pan troglodytes XM_51804589.7%
bos taurus NP_00103316685.6%
Pongo abelii XM_00281610987.8%
Mus musculus NM_026342.379%
Callithrix jacchus XP_00274446794.7%

Protein

The FAM114A2 protein is 505 amino acids long [5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66. [6] It is predicted to stay in the nucleus after translation [7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [8] This protein is thought to include a P loop [9] that suggests a role in ATP- and/or GTP-binding [10]

Gene

The FAM114A2 gene is located on chromosome 5 (5q31-33). [11] This gene has 14 exons spanning through its sequence. [5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs. [5] It is expressed at high levels in most tissues of the human body. [11] It is also highly expressed in tissues in the human brain [12]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000055147 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020523 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
  6. ↑ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#%5B%5D!
  7. ↑ PSORT WWW Server
  8. ↑ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
  9. ↑ "STRING: Functional protein association networks".
  10. ↑ Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID   2126155.
  11. 1 2 FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
  12. ↑ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Archived 2011-08-18 at the Wayback Machine

Further reading


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