FAM49A

FAM49A
Identifiers
Aliases	FAM49A , family with sequence similarity 49 member A
External IDs	MGI: 1261783 HomoloGene: 12657 GeneCards: FAM49A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	16,666,331 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	12,430,966 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; monocyte; ; middle temporal gyrus; ; superior frontal gyrus; ; prefrontal cortex; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex; ; Brodmann area 9; ; blood;
	Top expressed in
	olfactory tubercle; ; piriform cortex; ; cingulate gyrus; ; primary motor cortex; ; subiculum; ; visual cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; prefrontal cortex; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	81553
	76820
	ENSG00000197872
	ENSMUSG00000020589
	Q9H0Q0
	Q8BHZ0
	NM_030797
	NM_001146119 ; NM_029758 ; NM_001364432
	NP_110424
	NP_001139591 ; NP_084034 ; NP_001351361
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Family with sequence similarity 49, member A, also known as FAM49A, is a protein which in humans is encoded by the FAM49A gene.^[5]

Gene

Fam49A is located on human chromosome 2, at 2p24.3. It has 1512 base pairs in the reference sequence mRNA transcript.^[6]

Protein

The Fam49A gene product is a 323 amino acid protein. The protein contains two domains: Residues 15-319 comprise the "Domain of Unknown Function 1394" (DUF1394, Pfam PF07159). Residues 67->281 comprise the "Cytoplasmic Fragile X Interacting Superfamily" region.^[7]

Related Research Articles

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Transmembrane and TPR repeat-containing protein 2 is a protein that in humans is encoded by the TMTC2 gene.

Protein FAM32A is a protein that in humans is encoded by the FAM32A gene.

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Protein ENED is a protein that in humans is encoded by the FAM198B gene.

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UPF0528 protein FAM172A is a protein that in humans is encoded by the FAM172A gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197872 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020589 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FAM49A family with sequence similarity 49, member A".
↑ "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]". Nucleotide. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.
↑ "Protein - family with sequence similarity 49, member A [Homo sapiens]". Protein. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197872 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020589 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FAM49A family with sequence similarity 49, member A".

[urlNucleotide_-_family_with_sequence_similarity_49,_member_A_[Homo...-6] "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]". Nucleotide. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

[urlProtein_-_family_with_sequence_similarity_49,_member_A_[Homo...-7] "Protein - family with sequence similarity 49, member A [Homo sapiens]". Protein. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

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FAM49A

Contents

Gene

Protein

Related Research Articles

References

Further reading