FAM49A

FAM49A
Identifiers
Aliases	FAM49A , family with sequence similarity 49 member A
External IDs	MGI: 1261783; HomoloGene: 12657; GeneCards: FAM49A; OMA:FAM49A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p24.2 Start 16,549,459 bp [1] End 16,666,331 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 A1.1|12 5.63 cM Start 12,312,140 bp [2] End 12,430,966 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 monocyte middle temporal gyrus superior frontal gyrus prefrontal cortex entorhinal cortex dorsolateral prefrontal cortex orbitofrontal cortex primary visual cortex lateral nuclear group of thalamus Top expressed in olfactory tubercle piriform cortex cingulate gyrus primary motor cortex subiculum anterior amygdaloid area visual cortex subdivision of hippocampus Region I of hippocampus proper nucleus accumbens More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 81553 76820 Ensembl ENSG00000197872 ENSMUSG00000020589 UniProt Q9H0Q0 Q8BHZ0 RefSeq (mRNA) NM_030797 NM_001146119 NM_029758 NM_001364432 RefSeq (protein) NP_110424 NP_001139591 NP_084034 NP_001351361 Location (UCSC) Chr 2: 16.55 – 16.67 Mb Chr 12: 12.31 – 12.43 Mb PubMed search [3] [4]
Wikidata
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Family with sequence similarity 49, member A, also known as FAM49A, is a protein which in humans is encoded by the FAM49A gene. ^[5]

Gene

Fam49A is located on human chromosome 2, at 2p24.3. It has 1512 base pairs in the reference sequence mRNA transcript. ^[6]

Protein

The Fam49A gene product is a 323 amino acid protein. The protein contains two domains: Residues 15-319 comprise the "Domain of Unknown Function 1394" (DUF1394, Pfam PF07159). Residues 67->281 comprise the "Cytoplasmic Fragile X Interacting Superfamily" region. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000197872 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020589 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FAM49A family with sequence similarity 49, member A".
6. "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]". Nucleotide. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.
7. "Protein - family with sequence similarity 49, member A [Homo sapiens]". Protein. National Center for Biotechnology Information, United States National Institutes of Health. Retrieved 2009-05-09.

Further reading

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.