FAM60A

SINHCAF
Identifiers
Aliases	SINHCAF , C12orf14, TERA, L4, FAM60A, family with sequence similarity 60 member A, SIN3-HDAC complex associated factor
External IDs	OMIM: 615027; MGI: 1929091; HomoloGene: 10494; GeneCards: SINHCAF; OMA:SINHCAF - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p11.21 Start 31,280,584 bp [1] End 31,327,058 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G3 Start 148,822,533 bp [2] End 148,847,965 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence endometrium islet of Langerhans olfactory zone of nasal mucosa lymph node body of uterus tonsil rectum appendix Top expressed in genital tubercle tail of embryo epiblast embryo ventricular zone ganglionic eminence embryo zygote secondary oocyte primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Sin3 complex nucleus Biological process negative regulation of cell migration positive regulation of cell population proliferation negative regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58516 56306 Ensembl ENSG00000139146 ENSG00000276371 ENSMUSG00000039985 UniProt Q9NP50 Q8C8M1 RefSeq (mRNA) NM_001135811 NM_001135812 NM_021238 NM_019643 NM_001355645 NM_001361398 RefSeq (protein) NP_001129283 NP_001129284 NP_067061 NP_062617 NP_001342574 NP_001348327 Location (UCSC) Chr 12: 31.28 – 31.33 Mb Chr 6: 148.82 – 148.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein FAM60A is a protein that in humans is encoded by the FAM60A gene. ^{[5] [6]} The expression of FAM60A gene is higher in KRAS mutant non-small cell lung cancer. ^[7]

References

1. ENSG00000276371 GRCh38: Ensembl release 89: ENSG00000139146, ENSG00000276371 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039985 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
6. "Entrez Gene: FAM60A family with sequence similarity 60, member A".
7. Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN   1097-0215. PMC   5299512 . PMID   27859136.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID   15334068.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.