FAM60A

SINHCAF
Identifiers
Aliases	SINHCAF , C12orf14, TERA, L4, FAM60A, family with sequence similarity 60 member A, SIN3-HDAC complex associated factor
External IDs	OMIM: 615027 MGI: 1929091 HomoloGene: 10494 GeneCards: SINHCAF
Gene location (Human)
Chr.	Chromosome 12 (human)
End	31,327,058 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	148,847,965 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; endometrium; ; islet of Langerhans; ; lymph node; ; thymus; ; rectum; ; appendix; ; smooth muscle tissue; ; right uterine tube; ; myometrium;
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; mirror; ; ovary; ; yolk sac; ; neural tube; ; uterus; ; mesencephalon; ; placenta; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	Sin3 complex ; nucleus ;
Biological process	negative regulation of cell migration ; positive regulation of cell population proliferation ; negative regulation of cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	58516
	56306
	ENSG00000139146 ; ENSG00000276371
	ENSMUSG00000039985
	Q9NP50
	Q8C8M1
	NM_001135811 ; NM_001135812 ; NM_021238
	NM_019643 ; NM_001355645 ; NM_001361398
	NP_001129283 ; NP_001129284 ; NP_067061
	NP_062617 ; NP_001342574 ; NP_001348327
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Protein FAM60A is a protein that in humans is encoded by the FAM60A gene.^[5]^[6] The expression of FAM60A gene is higher in KRAS mutant non-small cell lung cancer.^[7]

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References

1 2 3 ENSG00000276371 GRCh38: Ensembl release 89: ENSG00000139146, ENSG00000276371 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039985 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
↑ "Entrez Gene: FAM60A family with sequence similarity 60, member A".
↑ Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512 . PMID 27859136.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID 15334068.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000276371 GRCh38: Ensembl release 89: ENSG00000139146, ENSG00000276371 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039985 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.

[entrez-6] "Entrez Gene: FAM60A family with sequence similarity 60, member A".

[7] Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512 . PMID 27859136.

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FAM60A

Related Research Articles

References

Further reading